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IRCT20160702028742N11 IRCT 2022-01-29 Shahid Beheshti University of Medical Sciences Calorie restriction and plasma brain-derived neurotrophic factor Effect of calorie restriction on blood pressure and plasma brain-derived neurotrophic factor in overweight or obese subjects 2022-02-19 anticipated 52 Complete https://irct.ir/trial/61549 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Basic scienece, Randomization description: The sequence of assigning individuals to the study groups is done using Random Allocation Software. The sequence will be placed in a sealed opaque envelope. N/A Hypertension. Intervention group: Low-calorie diet. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information"
public Javad Nasrollahzadeh
No. 7, Hafezi Ave., Farahzadi Blvd., Qods Town,
Tehran Iran (Islamic Republic of) 1981619573 +98 21 2207 7424 jnasrollahzadeh@gmail.com Shahid Beheshti University of Medical Sciences scientific Javad Nasrollahzadeh
No. 7, Hafezi Ave., Farahzadi Blvd., Qods Town,
Tehran Iran (Islamic Republic of) 1981619573 +98 21 2207 7424 jnasrollahzadeh@gmail.com Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Patients with a body mass index higher than 25 Regular use of antihypertensive drugs for at least the last 3 months non-smoker Haven't been under any weight-loss diet at least 3 months before participating in the study 40 years 70 years Both Taking antipsychotic, anticonvulsant drugs Cancer or stage 4 or 5 chronic or kidney disease Pregnancy or breastfeeding Any changes in the disease treatment plan during the study, including changes in the type and dose of drugs used to affect blood pressure or surgery• Insulin treated patients Taking omega 3 supplement I10 Essential (primary) hypertension Lifestyle Intervention group: Low-calorie diet Blood pressure. Timepoint: Baseline and the end of study. Method of measurement: Validated digital arm sphygmomanometer. Plasma brain-derived neurotrophic factor. Timepoint: Baseline and the end of study. Method of measurement: ٍ»]َُ. Plasma ICAM-1. Timepoint: Baseline and the end of study. Method of measurement: ELISA. Shahid Beheshti University of Medical Sciences Approved 2022-01-01 The Ethic committeeof National Nutrition and Food Technology Research Institute No. 7, West Arghavan Ave., Farahzadi Blvd., Qods Town, Tehran Tehran Iran (Islamic Republic of)