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IRCT20190917044797N2 IRCT 2022-02-05 The University of tabriz The effect of high-intensity interval training (HIIT) and vitamin D supplementation on older men The effect of 8 weeks of high-intensity interval training (HIIT) with and without vitamin D supplementation on some muscle atrophy indexes in older men 2022-02-09 anticipated 40 Complete https://irct.ir/trial/61494 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Other, Randomization description: At first, the subjects will be selected using a simple random method. Then, using a table of random numbers, they are divided into four groups: control, exercise, vitamin D and exercise + vitamin D. Therefore, each candidate will be assigned a two-digit number from 01.02.000 to 40. Starting from a point on the table of random numbers in the direction of the desired row or column, the same number of digits is determined for the selection of individuals (five-digit numbers whose last two digits are similar to the existing codes) that are randomly assigned to one of the groups It will be given. This will continue until the number of people in each group is completed. Therefore, the researcher will not have the option to change the status of the assignment or predict it. Random hiding will be done by a third party who does not participate in other stages of the intervention. N/A Sarcopenia. Intervention 1: Control group: without receiving supplements and exercise program. Intervention 2: Intervention group: The daily intake of 2000 international units of vitamin D per day will be done for eight weeks. Intervention 3: Intervention group: Group three (high-intensity interval training ): Subjects in the high-intensity interval training group will participate 3 days a week for 8 weeks of high-intensity interval training with an intensity of more than 75% of the reserve heart rate. Blood samples are taken at rest 48 hours before the start of training and 48 hours after the last training session. Intervention 4: Intervention group: Group four (High-intensity interval training +Vitamin D group): Subjects in the high-intensity interval training group will take vitamin D, 3 days a week, for 8 weeks of high-intensity interval training with an intensity of more than 75% of the reserve heart rate. During this period, 2,000 international units of vitamin D will be consumed every day. Blood samples are taken at rest 48 hours before the start of training and 48 hours after the last training session. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no more information
public Kaveh Baturak
29 Bahman Blvd., University of Tabriz
Tabriz Iran (Islamic Republic of) 5166616471 +98 41 3334 0081 Kawa.Baturak@gmail.com The University of tabriz scientific Javad Vakili
29 Bahman Blvd., University of Tabriz, Faculty of Physical Education and Sport Sciences
Tabriz Iran (Islamic Republic of) 5166616471 +98 41 3339 3257 Vakili@tabrizu.ac.ir The University of tabriz Iran (Islamic Republic of) Age range 60 to 75 years inactive (less than 90 minutes of regular exercise per week) Do not use drugs and anabolic supplements, blood pressure, anti-inflammatory and antioxidants 60 years 75 years Male The elderly are injured Metabolic and cardiovascular diseases M62.5 Muscle wasting and atrophy, not elsewhere classified Other Other Other Other Control group: without receiving supplements and exercise program Intervention group: The daily intake of 2000 international units of vitamin D per day will be done for eight weeks. Intervention group: Group three (high-intensity interval training ): Subjects in the high-intensity interval training group will participate 3 days a week for 8 weeks of high-intensity interval training with an intensity of more than 75% of the reserve heart rate. Blood samples are taken at rest 48 hours before the start of training and 48 hours after the last training session. Intervention group: Group four (High-intensity interval training +Vitamin D group): Subjects in the high-intensity interval training group will take vitamin D, 3 days a week, for 8 weeks of high-intensity interval training with an intensity of more than 75% of the reserve heart rate. During this period, 2,000 international units of vitamin D will be consumed every day. Blood samples are taken at rest 48 hours before the start of training and 48 hours after the last training session. Serum levels of vitamin D. Timepoint: 48 hours before and after 8 weeks of exercise training. Method of measurement: Using the ELISA method. Serum levels of Insulin-like hormone 1. Timepoint: 48 hours before and after 8 weeks of exercise training. Method of measurement: Using the ELISA method. Serum levels of myostatin hormone. Timepoint: 48 hours before and after 8 weeks of exercise training. Method of measurement: Using the ELISA method. MiRNA-1. Timepoint: 48 hours before and after 8 weeks of exercise training. Method of measurement: Real Time PCR technique. MiRNA-133a. Timepoint: 48 hours before and after 8 weeks of exercise training. Method of measurement: Real Time PCR technique. MiRNA-206. Timepoint: 48 hours before and after 8 weeks of exercise training. Method of measurement: Real Time PCR technique. The University of tabriz Approved 2022-01-02 Ethics committee of tabriz University 29 Bahman Blvd., University of Tabriz tabriz East Azarbaijan Iran (Islamic Republic of)