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IRCT20190325043107N26 IRCT 2022-01-21 Tabriz University of Medical Sciences Comparison of dexmetomedin and midazolam on hemodynamic changes during extubation of patients with a history of hypertension Comparison of the effects of dexmethomedin and midazolam on hemodynamic changes during extubation of patients with a history of hypertension candidates for non-emergency orthopedic surgery 2022-02-19 anticipated 100 Complete https://irct.ir/trial/61387 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Patients will be placed in one of two groups of midazolam or dexmethomedin, respectively, according to the purification list prepared with the help of Online statistical software (WWW.Randomizer.org). In this software, 100 people will be determined; Then, the patients' details will be entered into this software by entering the study and will be divided into two relevant groups by the software, Blinding description: The statistical consultant will be unaware of the grouping of patients, so he will be blind during the study. 2-3 Hemodynamic status. Intervention 1: Intervention group: Patients will receive dexmedetomedine at a rate of 0.6 mg /kg per hour ten minutes before extubation and their hemodynamic status (blood pressure and heart rate) for one minute every ten minutes after extubation. The load will be measured. Intervention 2: Control group: Patients will receive 0.02 mg /kg in the form of bolus in the ten minutes before extubation and their hemodynamic status (blood pressure and heart rate) for ten minutes after each extubation. It will be measured once a minute. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Masoud Parish
Shohada Hospital, Azadi Ave
Tabriz Iran (Islamic Republic of) 5165665631 +98 41 3335 7310 Drparishm@yahoo.com Tabriz University of Medical Sciences scientific Masoud Parish
Shohada Hospital, Azadi Ave
Tabriz Iran (Islamic Republic of) 5165665631 +98 41 3335 7310 Drparishm@yahoo.com Tabriz University of Medical Sciences Iran (Islamic Republic of) Candidates for orthopedic surgery require general anesthesia History of high blood pressure with the approval of a cardiologist Taking medications to control high blood pressure 18 years 75 years Both Uncontrolled high blood pressure Patients with difficult intubation Pregnant women R03.0 Elevated blood-pressure reading, without diagnosis of hypertension Prevention Prevention Intervention group: Patients will receive dexmedetomedine at a rate of 0.6 mg /kg per hour ten minutes before extubation and their hemodynamic status (blood pressure and heart rate) for one minute every ten minutes after extubation. The load will be measured. Control group: Patients will receive 0.02 mg /kg in the form of bolus in the ten minutes before extubation and their hemodynamic status (blood pressure and heart rate) for ten minutes after each extubation. It will be measured once a minute. Hemodynamic status. Timepoint: Every minute for ten minutes. Method of measurement: A mercury sphygmomanometer will be used to measure blood pressure and a pulse oximeter will be used to measure heart rate. Tabriz University of Medical Sciences Approved 2021-12-13 Ethics committee of Tabriz University of Medical Sciences Imam Reza Hospital, Azadi Ave Tabriz East Azarbaijan Iran (Islamic Republic of)