<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE trials [
<!ELEMENT trials (trial+)>

<!ELEMENT trial (main,contacts,countries,criteria,health_condition_code,health_condition_keyword,intervention_code,
          intervention_keyword,primary_outcome,secondary_outcome,secondary_sponsor,secondary_ids,source_support,ethics_reviews)>

<!ELEMENT main (trial_id,utrn?,reg_name,date_registration,primary_sponsor,public_title,acronym?,scientific_title,scientific_acronym?,
          date_enrolment,type_enrolment,target_size,recruitment_status,url?,study_type,study_design,phase,hc_freetext?,i_freetext?,results_actual_enrolment,results_date_completed,results_url_link,results_summary,           results_date_posted,results_date_first_publication,results_baseline_char,results_participant_flow,results_adverse_events,results_outcome_measures,results_url_protocol,results_IPD_plan, results_IPD_description)>
<!ELEMENT trial_id (#PCDATA)>
<!ELEMENT utrn (#PCDATA)>
<!ELEMENT reg_name (#PCDATA)>
<!ELEMENT date_registration (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT primary_sponsor (#PCDATA)>
<!ELEMENT public_title (#PCDATA)>
<!ELEMENT acronym (#PCDATA)>
<!ELEMENT scientific_title (#PCDATA)>
<!ELEMENT scientific_acronym (#PCDATA)>
<!ELEMENT date_enrolment (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT type_enrolment (#PCDATA)>
<!ELEMENT target_size (#PCDATA)>
<!ELEMENT recruitment_status (#PCDATA)><!-- Pending,Recruiting,Suspended,Complete,Other -->
<!ELEMENT url (#PCDATA)>
<!ELEMENT study_type (#PCDATA)><!-- interventional,observational -->
<!ELEMENT study_design (#PCDATA)>
<!ELEMENT phase (#PCDATA)>
<!ELEMENT hc_freetext (#PCDATA)>
<!ELEMENT i_freetext (#PCDATA)>
<!ELEMENT results_actual_enrolment (#PCDATA)>
<!ELEMENT results_date_completed (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_url_link (#PCDATA)>
<!ELEMENT results_summary (#PCDATA)>
<!ELEMENT results_date_posted (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_date_first_publication (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_baseline_char (#PCDATA)>
<!ELEMENT results_participant_flow (#PCDATA)>
<!ELEMENT results_adverse_events (#PCDATA)>
<!ELEMENT results_outcome_measures (#PCDATA)>
<!ELEMENT results_url_protocol (#PCDATA)>
<!ELEMENT results_IPD_plan (#PCDATA)>
<!ELEMENT results_IPD_description (#PCDATA)>


<!ELEMENT contacts (contact+)>
<!ELEMENT contact (type,firstname,middlename,lastname,address,city,country1,zip,telephone,email,affiliation)>
<!ELEMENT type (#PCDATA)><!-- Public,Scientific -->
<!ELEMENT firstname (#PCDATA)>
<!ELEMENT middlename (#PCDATA)>
<!ELEMENT lastname (#PCDATA)>
<!ELEMENT address (#PCDATA)>
<!ELEMENT city (#PCDATA)>
<!ELEMENT country1 (#PCDATA)>
<!ELEMENT zip (#PCDATA)>
<!ELEMENT telephone (#PCDATA)>
<!ELEMENT email (#PCDATA)>
<!ELEMENT affiliation (#PCDATA)>

<!ELEMENT countries (country2+)>
<!ELEMENT country2 (#PCDATA)>

<!ELEMENT criteria (inclusion_criteria,agemin,agemax,gender,exclusion_criteria)>
<!ELEMENT inclusion_criteria (#PCDATA)>
<!ELEMENT agemin (#PCDATA)>
<!ELEMENT agemax (#PCDATA)>
<!ELEMENT gender (#PCDATA)>
<!ELEMENT exclusion_criteria (#PCDATA)>

<!ELEMENT health_condition_code (hc_code+)>
<!ELEMENT hc_code (#PCDATA)>

<!ELEMENT health_condition_keyword (hc_keyword+)>
<!ELEMENT hc_keyword (#PCDATA)>

<!ELEMENT intervention_code (i_code+)>
<!ELEMENT i_code (#PCDATA)>

<!ELEMENT intervention_keyword (i_keyword+)>
<!ELEMENT i_keyword (#PCDATA)>

<!ELEMENT primary_outcome (prim_outcome+)>
<!ELEMENT prim_outcome (#PCDATA)>

<!ELEMENT secondary_outcome (sec_outcome+)>
<!ELEMENT sec_outcome (#PCDATA)>

<!ELEMENT secondary_sponsor (sponsor_name+)>
<!ELEMENT sponsor_name (#PCDATA)>

<!ELEMENT secondary_ids (secondary_id+)>
<!ELEMENT secondary_id (sec_id,issuing_authority)>
<!ELEMENT sec_id (#PCDATA)>
<!ELEMENT issuing_authority (#PCDATA)>

<!ELEMENT source_support (source_name+)>
<!ELEMENT source_name (#PCDATA)>

<!ELEMENT ethics_reviews (ethics_review+)>
<!ELEMENT ethics_review (status,approval_date,contact_name,contact_address,contact_phone,contact_email)>
<!ELEMENT status (#PCDATA)><!-- Not approved,Approved,NA -->
<!ELEMENT approval_date (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT contact_name (#PCDATA)>
<!ELEMENT contact_address (#PCDATA)>
<!ELEMENT contact_phone (#PCDATA)>
<!ELEMENT contact_email (#PCDATA)>
]>
<trials>
  <trial>
    <main>
      <trial_id>IRCT20220111053693N1</trial_id>
      <utrn></utrn>
      <reg_name>IRCT</reg_name>
      <date_registration>2022-01-21</date_registration>
      <primary_sponsor>Riphah International University , Lahore, Pakistan</primary_sponsor>
      <public_title>Comparison Of Autogenic Drainage &amp; Active Cycle Of Breathing Techniques In Patients With Pneumonia</public_title>
      <acronym>nil</acronym>
      <scientific_title>Comparison Of Autogenic Drainage &amp; Active Cycle Of Breathing Techniques In Patients With Pneumonia</scientific_title>
      <scientific_acronym></scientific_acronym>
      <date_enrolment>2021-06-05</date_enrolment>
      <type_enrolment>anticipated</type_enrolment>
      <target_size>16</target_size>
      <recruitment_status>Complete</recruitment_status>
      <url>https://irct.ir/trial/61368</url>
      <study_type>interventional</study_type>
      <study_design>Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Other design features: nil, Randomization description: This study was conducted at Gulab Devi Chest Hospital Lahore, Pakistan. This study was randomized clinical trial. Total twenty subjects were assigned randomly by using Convenient sampling technique into two groups. we will randomly choose the patients who will visit the hospital, having pneumonia and those who will meet our inclusion criteria. These patients will be allocated in 2 groups according to our convivence.</study_design>
      <phase>N/A</phase>
      <hc_freetext>Pneumonia is inflammation of the lungs and fluid collection in the alveoli. The two most common organisms responsible for pneumonia in low‐income countries are Streptococcus pneumoniae and Haemophilus influenzae . Children with pneumonia are treated with antibiotics, with hospitalisation and oxygen supplementation required in some cases, depending on disease severity. Accumulation of secretions in the airways due to respiratory infection contributes to the worsening of clinical symptoms and leads to an increase in airway resistance with each breath Signs and symptoms that are useful in diagnosing pneumonia are fever, tachypnoea, nasal flaring, cough, breathlessness, lower chest wall indrawing, and reduced oxygen saturation The gold standard for diagnosing pneumonia according to clinical guidelines is the presence of lung infiltrates indicated by chest radiography..</hc_freetext>
      <i_freetext>Intervention 1: In this study the sample size is 16, and is divided into 2 groups. Intervention group 1 and interventional group 2. Each group contain 8 individuals. Interventional group 1 will receive autogenic drainage along with percussion. The autogenic drainage technique tends to be practiced in sitting, and consists of 3 phases:1.	Un-sticking – this mobilizes secretions in the small airways at the bottom of the lungs. Technique: big breath out, small breath in2.	Collecting – this gathers the secretions and pushes them up the lungs into the main airways. Technique: middle sized breaths in and out3.	Evacuating – this gets the secretions right to the back of the throat where they can be coughed out easily. Coughing before this phase is discouraged. Technique: take in as much air as possible then slowly sigh out. Gentle active huffs then used to remove the secretions from the body through the mouth. Intervention 2: Intervention group 2 will be given active cycle breathing technique along with percussion.  Active cycle breathing technique consists of 4 stages:1.	Breathing control – This is gentle breathing to allow you to relax and concentrate. With your hands gently resting on your tummy, concentrate on feeling your tummy rise and fall with each gentle breath in and out. Your breath out should be slow, almost like a sigh.2.	Thoracic expansion (deep breaths) – This gets the air right down to the bottom of the lungs where it can loosen the phlegm. The breath in through your nose should be nice and slow, you should be able to feel your lungs filling up, when you feel like you have as much air in as is possible I want you to hold it there just for a few seconds, then gently breathe out through your mouth nice and slowly.3.	Forced expiration (huff) – This helps force the phlegm up and out of your lungs. To carry out the technique effectively you need to pretend you have a mirror in front of you; take a normal breath in then huff the air out as if you are steaming up the mirror. This sometimes causes an acute onset of coughing.4.	Cough – This allows you to get the phlegm up and out of your mouth, coughs are tiring and so should only be completed when you feel like the phlegm is just in the back of your throat. If the technique is used following surgery, a towel can be held over the scar site to ease the pressure on the wound and reduce pain whilst coughing.</i_freetext>
      <results_actual_enrolment></results_actual_enrolment>
      <results_date_completed></results_date_completed>
      <results_url_link></results_url_link>
      <results_summary></results_summary>
      <results_date_posted></results_date_posted>
      <results_date_first_publication></results_date_first_publication>
      <results_baseline_char></results_baseline_char>
      <results_participant_flow></results_participant_flow>
      <results_adverse_events></results_adverse_events>
      <results_outcome_measures></results_outcome_measures>
      <results_url_protocol></results_url_protocol>
      <results_IPD_plan>No - There is not a plan to make this available</results_IPD_plan>
      <results_IPD_description>Justification or reason for not sharing IPD is nil</results_IPD_description>
    </main>
    <contacts>
      <contact>
        <type>public</type>
        <firstname>Azed Ahsaan</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>Ward no 14 near ubl bank jampur district Rajanpur</address>
        <city>Jampur</city>
        <country1>Pakistan</country1>
        <zip>33500</zip>
        <telephone>+92 335 6055553</telephone>
        <email>azedahsaan786@gmail.com</email>
        <affiliation>Riphah international university lahore</affiliation>
      </contact>
      <contact>
        <type>scientific</type>
        <firstname>Azed Ahsaan</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>Ward no 14 near ubl bank jampur district Rajanpur</address>
        <city>Jampur</city>
        <country1>Pakistan</country1>
        <zip>33500</zip>
        <telephone>+92 335 6055553</telephone>
        <email>azedahsaan786@gmail.com</email>
        <affiliation>Riphah international university lahore</affiliation>
      </contact>
    </contacts>
    <countries>
      <country2>Pakistan</country2>
    </countries>
    <criteria>
      <inclusion_criteria>Patients aged 35- 60 years.
PNEUMONIA SEVERITY INDEX (PORT SCORE)
CLASS I TO III
Moderate to severe Grades for Severity of a Pulmonary Function Test Abnormality</inclusion_criteria>
      <agemin>35 years</agemin>
      <agemax>60 years</agemax>
      <gender>Both</gender>
      <exclusion_criteria>Patients with secondary pneumonia-that is, as a complication of dysfunction of respiratory muscles,
Chronic bronchitis,
Emphysema,
Asthma
Patients with known pulmonary tuberculosis or lung cancer.
Intellectually impaired</exclusion_criteria>
    </criteria>
    <health_condition_code>
      <hc_code></hc_code>
    </health_condition_code>
    <health_condition_keyword>
      <hc_keyword></hc_keyword>
    </health_condition_keyword>
    <intervention_code>
      <i_code>Rehabilitation</i_code>
      <i_code>Rehabilitation</i_code>
    </intervention_code>
    <intervention_keyword>
      <i_keyword>In this study the sample size is 16, and is divided into 2 groups. Intervention group 1 and interventional group 2. Each group contain 8 individuals. Interventional group 1 will receive autogenic drainage along with percussion. The autogenic drainage technique tends to be practiced in sitting, and consists of 3 phases:1.	Un-sticking – this mobilizes secretions in the small airways at the bottom of the lungs. Technique: big breath out, small breath in2.	Collecting – this gathers the secretions and pushes them up the lungs into the main airways. Technique: middle sized breaths in and out3.	Evacuating – this gets the secretions right to the back of the throat where they can be coughed out easily. Coughing before this phase is discouraged. Technique: take in as much air as possible then slowly sigh out. Gentle active huffs then used to remove the secretions from the body through the mouth.</i_keyword>
      <i_keyword>Intervention group 2 will be given active cycle breathing technique along with percussion.  Active cycle breathing technique consists of 4 stages:1.	Breathing control – This is gentle breathing to allow you to relax and concentrate. With your hands gently resting on your tummy, concentrate on feeling your tummy rise and fall with each gentle breath in and out. Your breath out should be slow, almost like a sigh.2.	Thoracic expansion (deep breaths) – This gets the air right down to the bottom of the lungs where it can loosen the phlegm. The breath in through your nose should be nice and slow, you should be able to feel your lungs filling up, when you feel like you have as much air in as is possible I want you to hold it there just for a few seconds, then gently breathe out through your mouth nice and slowly.3.	Forced expiration (huff) – This helps force the phlegm up and out of your lungs. To carry out the technique effectively you need to pretend you have a mirror in front of you; take a normal breath in then huff the air out as if you are steaming up the mirror. This sometimes causes an acute onset of coughing.4.	Cough – This allows you to get the phlegm up and out of your mouth, coughs are tiring and so should only be completed when you feel like the phlegm is just in the back of your throat. If the technique is used following surgery, a towel can be held over the scar site to ease the pressure on the wound and reduce pain whilst coughing</i_keyword>
    </intervention_keyword>
    <primary_outcome>
      <prim_outcome>Forced Vital Capacity (FVC). Timepoint: Measurements will be repeated after 4 weeks of 1st intervention. Method of measurement: The pulmonary function variables which will be assessed would be the   Forced Vital   Capacity (FVC) with the use of a spirometer. A   brief   description   about   the assessment   procedure   including   technical   steps   to   obtain pulmonary  function  data  and  variables  will be explained to  each subject.  After 2–3  tidal  breaths,  subjects  will be  asked  to  inhale deeply to total lung capacity and then immediately exhale rapidly (without  any  pause)  through  a  disposable  mouthpiece  until  as much air as possible has been expelled from the lungs.  The test will be performed with each subject in in  high  sitting position. The assessment  will be  repeated  3  times  after  adequate  rest.  The average  values  of  the  forced  vital  capacity  (FVC) will be recorded.</prim_outcome>
      <prim_outcome>Forced Expiratory Volume in one second (FEV1). Timepoint: Measurements will be repeated after 4 weeks of 1st intervention. Method of measurement: The pulmonary function variables which will be assessed would be the Forced   Expiratory Volume in one second (FEV1) with the use of a spirometer. A   brief   description   about   the assessment   procedure   including   technical   steps   to   obtain pulmonary  function  data  and  variables  will be explained to  each subject.  After 2–3  tidal  breaths,  subjects  will be  asked  to  inhale deeply to total lung capacity and then immediately exhale rapidly (without  any  pause)  through  a  disposable  mouthpiece  until  as much air as possible has been expelled from the lungs.  The test will be performed with each subject in in  high  sitting position. The assessment  will be  repeated  3  times  after  adequate  rest.  The average  values  of forced expiratory volume in the first second (FEV1) will be recorded.</prim_outcome>
    </primary_outcome>
    <secondary_outcome>
      <sec_outcome>The oxygen hemoglobin saturation (SpO2). Timepoint: Measurements will be repeated after 4 weeks of 1st intervention. Method of measurement: The oxygen hemoglobin saturation (SpO2) will be assessed using a non-invasive  pulse  oximeter.</sec_outcome>
    </secondary_outcome>
    <secondary_sponsor>
      <sponsor_name></sponsor_name>
    </secondary_sponsor>
    <secondary_ids>
      <secondary_id>
        <sec_id></sec_id>
        <issuing_authority></issuing_authority>
      </secondary_id>
    </secondary_ids>
    <source_support>
      <source_name>Riphah University</source_name>
    </source_support>
    <ethics_reviews>
      <ethics_review>
        <status>Approved</status>
        <approval_date>2021-03-19</approval_date>
        <contact_name>Riphah Ethical Committee</contact_name>
        <contact_address>Township Lahore Lahore Punjab Pakistan</contact_address>
        <contact_phone></contact_phone>
        <contact_email></contact_email>
      </ethics_review>
    </ethics_reviews>
  </trial>
</trials>
