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IRCT20210804052071N1 IRCT 2022-03-03 Sabzevar University of Medical Sciences Comparison of the effect of Aspirin at doses of 80 and 160 mg on the prevention of preeclampsia in women with abnormal Doppler ultrasound of the uterine artery Comparison of the effect of Aspirin at doses of 80 and 160 mg on the prevention of preeclampsia in women with abnormal Doppler ultrasound of the uterine artery 2022-01-21 anticipated 300 Complete https://irct.ir/trial/61197 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: atients with the above conditions in two groups are randomly entered into one of the two intervention or control groups by blocking method (quadruple blocks). Thus, various quadrilateral blocks were created (AABB, BBAA, ABAB, BABA, ABBA and BABA). One of these blocks will be randomly selected and patients will be divided into one of two groups A or B, Blinding description: The way of participant blindness is that she will receive and use a certain number of drugs in an unnamed and labeled envelopes.The investigators, participants, and evaluators will be blinded to assignment into the two groups (the groups taking the ASA+ ASA or taking the ASA+ placebo). 3 Preeclampsia. Intervention 1: Intervention group: Pregnant women who will take aspirin 80 mg. Aspirin 80 mg from Galenus Pharmaceutical Company will be taken orally once a day from the time of enrollment until the end of pregnancy. Intervention 2: Intervention group: Pregnant women who will take aspirin 160 mg. Aspirin 80 mg from Galenus Pharmaceutical Company will be taken orally 2 times a day from the time of enrollment until the end of pregnancy. Yes - There is a plan to make this available What will be shared: A piece of data such as information about the main outcome or the possibility of sharing. When: Access period starts 6 months after the results are published To whom: The data will be available only to researchers working in academic and scientific institutions Conditions: Necessary conditions for sending a request for access to the data or documents of the plan approval form in medical universities. Where to obtain: The request for data will be sent via email and will be answered within a week after review. How to obtain: The request for data will be sent via email and will be answered within a week after review. Comments:
public Mitra Eftekhari Yazdi
Kashefi St, Mobini Hospital
Sabzevar Iran (Islamic Republic of) 9313856776 +98 51 4423 8100 m_eftekhari1144@yahoo.com Sabzevar University of Medical Sciences scientific Mitra Eftekhari Yazdi
Kashefi St., Mobini Hospital
Sabzevar Iran (Islamic Republic of) 9313856776 +98 51 4423 8100 m_eftekhari1144@yahoo.com Sabzevar University of Medical Sciences Iran (Islamic Republic of) Pregnant mothers at 18 to 22 weeks with impaired uterine artery Doppler Being single 15 years 45 years Female Premature birth for reasons other than blood pressure The mother's unwillingness to continue cooperating Not taking the right medication O14 Pre-eclampsia Treatment - Drugs Treatment - Drugs Intervention group: Pregnant women who will take aspirin 80 mg. Aspirin 80 mg from Galenus Pharmaceutical Company will be taken orally once a day from the time of enrollment until the end of pregnancy. Intervention group: Pregnant women who will take aspirin 160 mg. Aspirin 80 mg from Galenus Pharmaceutical Company will be taken orally 2 times a day from the time of enrollment until the end of pregnancy. Preeclampsia. Timepoint: During pregnancy up to 40 days after delivery. Method of measurement: Mercury sphygmomanometer, urine test. Sabzevar University of Medical Sciences Approved 2021-12-29 Ethics committee of Sabzevar University of Medical Sciences Mobini Haspital Sabzevar Razavi Khorasan Iran (Islamic Republic of)