IRCT201608115623N87 IRCT 2016-08-26 Vice chancellor for research, Iran University of Medical Sciences Effect of supplementation in treatment of women with polycystic ovary syndrome Clinical trial of the effect of combined vitamin D, K and calcium supplementation compared with the placebo on metabolic profiles in women with polycystic ovary syndrome 2016-07-02 anticipated 60 Complete https://irct.ir/trial/6117 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: To decrease potential confounding effects, after balanced blocked randomization, all participants will be allocated into two treatment groups to take either supplementation or placebo. Randomization will be done by the use of Stat Trek software. Participants, investigators or the assessors of the outcomes are also unaware of the study groups, Blinding description: Participants, investigators or the assessors of the outcomes are unaware of the study groups. 3 Polycystic ovary syndrome. Intervention 1: Intervention group: Vitamin D, K and calcium supplements, 400 IU vitamin D+ 180 µg vitamin K+1000 mg calcium (Aryan Salamat, Tehran, Iran), daily, for 8 weeks orally. Intervention 2: Control group: Placebo capsule (Barij Essence, Kashan, Iran), daily for 8 weeks orally. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Undecided - It is not yet known if there will be a plan to make this available.