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IRCT20190325043107N25 IRCT 2022-01-05 Tabriz University of Medical Sciences Effect of tranexamic acid on homeostasis after tibial stereotomy Evaluation of the effect of tranexamic acid on homeostasis after tibial osteotomy 2022-01-20 anticipated 120 Complete https://irct.ir/trial/61069 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Patients were divided into four groups by quadruple block method; For this purpose, 4 sheets of paper were prepared and the letter A was written on two sheets and the letter B was written on the sheet; The sheets were then placed in a sealed container and each patient who came was given one of the sheets by the statistical consultant and the person was divided into two groups based on it. 2-3 Bleeding. Intervention 1: Intervention group(1): This group will be given 15 kg / mg tranexamic acid as an intravenous infusion over 20 minutes and then a full intravenous infusion at a dose of 1 mg / kg per hour until the end of surgery. Intervention 2: Intervention group(2): In this group, topical tranexamic acid will be injected. In this group, 500 mg of traxamic acid will be injected at the surgical site 15 minutes before the start of surgery. Intervention 3: Control group: Fifteen milliliters of normal saline will be given to this group as an intravenous infusion over 20 minutes, followed by a full intravenous infusion at a dose of one milliliter per hour until the end of surgery. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Not more information
public Jafar Soleimanpour Mokhtarmanand
Imam Reza Hospital, Azadi Ave
Tabriz Iran (Islamic Republic of) 5165665631 +98 41 3335 7310 Mkhanbabayi@yahoo.com Tabriz University of Medical Sciences scientific Gholamreza Khorrami
Imam Reza Hospital, Azadi Ave
Tabriz Iran (Islamic Republic of) 5165665631 +98 41 3335 7310 GH_khorami@yahoo.com Tabriz University of Medical Sciences Iran (Islamic Republic of) Osteoarthritis of the knee joint Candidate for surgery 18 years 75 years Both History of previous knee surgery Disorders of homeostasis system Taking blood thinners History of deep vein thrombosis Pathology in the outer part of the knee D59.6 Hemoglobinuria due to hemolysis from other external causes Treatment - Drugs Treatment - Drugs Placebo Intervention group(1): This group will be given 15 kg / mg tranexamic acid as an intravenous infusion over 20 minutes and then a full intravenous infusion at a dose of 1 mg / kg per hour until the end of surgery. Intervention group(2): In this group, topical tranexamic acid will be injected. In this group, 500 mg of traxamic acid will be injected at the surgical site 15 minutes before the start of surgery. Control group: Fifteen milliliters of normal saline will be given to this group as an intravenous infusion over 20 minutes, followed by a full intravenous infusion at a dose of one milliliter per hour until the end of surgery. Bleeding. Timepoint: Every six hours to 72 hours after surgery. Method of measurement: View blood storage drains. Tabriz University of Medical Sciences Approved 2020-09-07 Ethics committee of Tabriz University of Medical Sciences Imam Reza Hospital, Azadi Ave Tabriz East Azarbaijan Iran (Islamic Republic of)