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IRCT20120911010811N2 IRCT 2022-01-13 Mashhad University of Medical Sciences Comparison of pediatric intravenous acetaminophen and acetaminophen suppository in hernia surgery Comparison of caudal block, intravenous and suppository acetaminophen preemptive analgesia in pediatric inguinal herniotomy 2022-01-21 anticipated 159 Complete https://irct.ir/trial/60978 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization with table of random numbers available at ''www.randomization.com'' website will be used. Numbers will be placed in sealed envelopes and each envelope is assigned to one participant placing them in one of the two groups, Blinding description: In this study, participants are not aware of the intervention and the type of treatment received . Also, outcome assessors are unaware of how patients are grouped. 2-3 Patients with inguinal hernia who are candidates for surgery. Intervention 1: Control group: Children who are candidates for inguinal hernia repair surgery, general anesthesia is performed with 1 mg / kg fentanyl, 3 to 5 mg / kg 1% propofol and 0.5 mg / kg atracurium, the patient is intubated After induction and before surgery, they are placed in a caudal block with 0.25% bupivacaine at a dose of 1 ml / kg. At the end of surgery and extubation, the patient is transferred to recovery and the patient's pain is measured according to the behaivorial-FLACC criterion. Intervention 2: Intervention group: Children who are candidates for inguinal hernia repair surgery: General anesthesia is performed with 1 mg / kg fentanyl, 3 to 5 mg / kg 1% propofol, and 0.5 mg / kg atracurium. The patient is intubated, after induction and before surgery, intravenous acetaminophen is prescribed at 12.5 mg / kg, after the end of surgery and extubation, transferred to recovery and the patient's pain is measured according to the behaivorial-FLACC criterion. Intervention 3: Intervention group: Children who are candidates for inguinal hernia repair surgery: General anesthesia is performed with 1 mg / kg fentanyl, 3 to 5 mg / kg 1% propofol, and 0.5 mg / kg atracurium. The patient is intubated, after induction and before surgery, acetaminophen suppositories are given at a dose of 15 mg / kg, after the end of surgery and extubation, transferred to recovery and the patient's pain is measured according to the behaivorial-FLACC criterion. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Relevant partners should be consulted to publish the data
public Alireza Sabzevari
Akbar Hospital, television Square
Mashhad Iran (Islamic Republic of) 9176999311 +98 51 3871 3803 sabzevaria@mums.ac.ir Mashhad University of Medical Sciences scientific Alireza Sabzevari
Akbar Hospital, television Square
Mashhad Iran (Islamic Republic of) 9176999311 +98 51 3871 3803 sabzevaria@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Candidate for inguinal hernia repair surgery Parents' consent based on children's participation in the study Participants are children from 6 months to 3 years 6 months 3 years Both History of bupivacaine allergy Existence of local infection in the spine Presence of pilonidal cyst History of acetaminophen allergy History of liver problems History of heart disease K40 Inguinal hernia Treatment - Drugs Treatment - Drugs Treatment - Drugs Control group: Children who are candidates for inguinal hernia repair surgery, general anesthesia is performed with 1 mg / kg fentanyl, 3 to 5 mg / kg 1% propofol and 0.5 mg / kg atracurium, the patient is intubated After induction and before surgery, they are placed in a caudal block with 0.25% bupivacaine at a dose of 1 ml / kg. At the end of surgery and extubation, the patient is transferred to recovery and the patient's pain is measured according to the behaivorial-FLACC criterion. Intervention group: Children who are candidates for inguinal hernia repair surgery: General anesthesia is performed with 1 mg / kg fentanyl, 3 to 5 mg / kg 1% propofol, and 0.5 mg / kg atracurium. The patient is intubated, after induction and before surgery, intravenous acetaminophen is prescribed at 12.5 mg / kg, after the end of surgery and extubation, transferred to recovery and the patient's pain is measured according to the behaivorial-FLACC criterion. Intervention group: Children who are candidates for inguinal hernia repair surgery: General anesthesia is performed with 1 mg / kg fentanyl, 3 to 5 mg / kg 1% propofol, and 0.5 mg / kg atracurium. The patient is intubated, after induction and before surgery, acetaminophen suppositories are given at a dose of 15 mg / kg, after the end of surgery and extubation, transferred to recovery and the patient's pain is measured according to the behaivorial-FLACC criterion. The amount of analgesia. Timepoint: After inguinal hernia surgery in recovery. Method of measurement: Based on the behaivorial-FLACC criteria. Mashhad University of Medical Sciences Approved 2021-11-30 Ethic committe of Mashhad university of Medical Sciences Ghoreyshi Building, Daneshgah street, Mashhad Mashhad Razavi Khorasan Iran (Islamic Republic of)