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IRCT20181208041882N6 IRCT 2022-01-09 Yazd University of Medical Sciences Topical N-Acetylcysteine and Zinc Oxide in the Treatment of Diaper Dermatitis Comparison of the Effectiveness of Topical N-Acetylcysteine and Zinc Oxide in the Treatment of Diaper Dermatitis 2019-06-22 anticipated 44 Complete https://irct.ir/trial/60969 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Forty-four of screened patients met the inclusion criteria. These were randomly allocated to the intervention group (n=22) and control group (n=22) using an online randomization tool: graphpad.com/quickcalcs/randMenu.Then the same numbered N-acetylcysteine or Zinc Oxide containers were given to the caregivers for use in the intervention and control groups. One of the researchers (Behrooz Heydari) was responsible for this assignment and was the only member aware of randomization and allocation. He did not participate in the evaluation of outcomes, Blinding description: In this study participants, the caregivers, and one of the researchers ( Nazgol Kermanshahi) collecting and assessing data were unaware of the assigned intervention. 3 Diaper Dermatitis. Intervention 1: Intervention group: After 3% N-acetylcysteine cream formulation, use topically after each diaper change for 5 days. Intervention 2: Control group: Topical zinc oxide ointment 20% (Caspian Company), applied topically after each diaper change for 5 days. Yes - There is a plan to make this available What will be shared: After nonrecognition, all data can be shared When: 6 months after publication To whom: All of researchers Conditions: Nothing Where to obtain: Behrooz Heydari email: b.heydari@ssu.ac.ir How to obtain: Request your information by email. The data will be sent after a week Comments:
public Behrooz Heydari
Shahid sadoughi university of medical sciences,shohadaye Gomnam Blvd,Alem Sq
Yazd Iran (Islamic Republic of) 8915173143 +98 35 3820 3410 b.heydari@ssu.ac.ir Yazd University of Medical Sciences scientific Behrooz Heydari
Shahid Sadoughi University of medical sciences Shohadaye Gomnam Blv Alem Sq
Yazd Iran (Islamic Republic of) 8915173143 +98 35 3820 3410 b.heydari@ssu.ac.ir Yazd University of Medical Sciences Iran (Islamic Republic of) Patients aged less than 2 years Diagnosed with diaper dermatitis no limit 2 years Both Secondary infectious dermatitis Use of any corticosteroid A history of atopic dermatitis, candidiasis, or seborrheic dermatitis Birth defect L22 Diaper dermatitis Treatment - Drugs Treatment - Drugs Intervention group: After 3% N-acetylcysteine cream formulation, use topically after each diaper change for 5 days Control group: Topical zinc oxide ointment 20% (Caspian Company), applied topically after each diaper change for 5 days Evaluation of erythema severity. Timepoint: Days one, three and five after the intervention. Method of measurement: Based on scoring the severity of diaper dermatitis scale. Patients' recovery compared to the first day of intervention. Timepoint: The first, third and fifth day after intervention. Method of measurement: Observation and comparison of erythema severity, extent of dermatitis and clinical manifestations. Yazd University of Medical Sciences Approved 2019-05-19 Ethics committee of Shahid Sadoughi university of medical science Shahid Sadoughi university of medical science, Shohadai Gomnam Blvd, Professor Hesabi Blvd Yazd Yazd Iran (Islamic Republic of)