]>
IRCT20211225053517N1 IRCT 2022-02-11 Esfahan University of Medical Sciences Evaluation the effects of vasodilator (nitroglycerin-TNG) in Cardioplegic Solution myocardial ischemia in patients treated with coronary artery bypass graft surgery in Chamran Hospital, Isfahan Evaluation the effects of vasodilator (nitroglycerin-TNG) in Cardioplegic Solution myocardial ischemia in patients treated with coronary artery bypass graft surgery in Chamran Hospital, Isfahan 2021-09-23 anticipated 44 Complete https://irct.ir/trial/60869 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: Sampling method is a simple individual randomization method that was performed using SPSS statistical software and blind three-way, Blinding description: Lack of information of the participant evaluating the outcome and analyzing the data. 1-2 Cardiovascular surgery. Intervention 1: Addition of injectable nitroglycerin to weight-based cardioplegia solution. Intervention 2: Control group: Nitroglycerin-free cardioplegia solution. Yes - There is a plan to make this available What will be shared: The result of the clinical trial will be published after the thesis is approved When: Access period starts 6 months after the results are published To whom: Researcher working in academic and scientific institutions Conditions: For use in future studies Where to obtain: Fatemeh Amiri Dehnavi How to obtain: Refer to the database of Isfahan University, thesis section Comments:
public Fatemeh Amiri
No. 110 Dastgerd St., Shahid Safarian Alley, 2 dead end,
Esfahan Iran (Islamic Republic of) 8174854511 +98 31 3776 8614 amirif319@gmail.com Esfahan University of Medical Sciences scientific Dr. Seyed Alireza Hosseini
Shahid Chamran Hospital
Esfahan Iran (Islamic Republic of) 8166173414 +98 31 3260 0961 hosseiny@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) In this study, patients with Serener's disease who will undergo CABG. EF more than 40% Age between 35 and 70 years Candidates for non-emergency surgery Pump time between one to two hours Arrest time between 30 -100 minutes 35 years 70 years Both Patients in cardiogenic shock and patients receiving known antioxidants such as captopril mannitol or allopurinol will be excluded from the study. Also unpredictable events that disrupt the normal surgical process, such as the use of an intra-aortic pump balloon and ECMO, cardiac arrest, The length of stay in the ICU for more than five days will result in the removal of the sample. I25.1 Atherosclerotic heart disease of native coronary artery Other Other Addition of injectable nitroglycerin to weight-based cardioplegia solution Control group: Nitroglycerin-free cardioplegia solution Evaluation of changes in troponin and CPK in patients undergoing open heart surgery with nitroglycerin effect. Timepoint: Measurement of troponin and CPK before and after surgery. Method of measurement: Vidas device for troponin check and BT3000 device for CPK check. Esfahan University of Medical Sciences Approved 2021-12-26 Ethics Committee of Isfahan University of Medical Sciences No 110 Dastgerd Street, Shahid Safarian 2 Esfahan Isfehan Iran (Islamic Republic of)