IRCT20211123053154N1 IRCT 2022-04-03 Shahid Beheshti University of Medical Sciences Comparative evaluation of the sedative effects of Intra-Venous Propofol / Fentanyl combination Vs. Ketamine / Midazolam combination for uncooperative children undergoing dental procedures. Comparative evaluation of the sedative effects of Intra-Venous Propofol / Fentanyl combination Vs. Ketamine / Midazolam combination for uncooperative 2-6 year old children undergoing dental procedures. 2022-01-05 anticipated 24 Complete https://irct.ir/trial/60823 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Crossover, Purpose: Treatment, Randomization description: Patients will be divided in two groups AB and BA, in which the AB group prescribed drug A and then drug B. The order of drug administration in group BA will be reversed, Blinding description: The patients and the therapist are not aware of sedative medication regimen during dental procedures. The anesthesiologist and the care team will only be aware about that. 3 Dental treatment of uncooperative children under sedation conditions. Intervention 1: In group AB, combination of Fentanyl (dose: 1μgr/kg) and Propofol (dose: 2 mg/kg) will be injected in the intervention phase and the first session of dental treatment for sedation induction. Propofol injection will continue (dose: 150μgr/kg/H) for sedation maintenance. Intervention 2: In group BA, combination of Ketamine (dose: 2mgr/kg) and Midazolam (dose: 0.2 mg/kg) will be injected in the intervention phase and the first session of dental treatment for sedation induction. No - There is not a plan to make this available Justification or reason for not sharing IPD is Observance of ethical standards