IRCT20190423043360N1 IRCT 2023-02-27 Shahid Beheshti University of Medical Sciences Investigation of the effect of platelet-rich fibrin on skin thickness Evaluation of the effect of topical injection of platelet-rich fibrin on the thickness of nasal skin in people undergoing rhinoplasty by ultrasonography 2022-03-21 anticipated 10 Complete https://irct.ir/trial/60717 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment, Other design features: The effectiveness of platelet-rich fibrin on improving the thickness of nasal skin has not been studied in Iran. 2 . After a complete explanation about the study and obtaining their consent, first 30 cc of venous blood samples are taken from the person's blood and collected in 15 ml plastic coated tubes without the use of anticoagulants. Then the tubes are immediately placed opposite each other inside the centrifuge and centrifuged at 800 revolutions per minute for four minutes. The yellow-orange upper liquid obtained is ready for injection. The above actions are performed with all aseptic precautions. The participants undergo ultrasound examination four times in order to compare the thickness of the nasal skin. The first stage is before the injection and the next three stages are one, two and three weeks after the injection. Ultrasound will be performed by a high-frequency linear probe by the center's expert radiologists who are familiar with ultrasound. During the ultrasound process, the thickness of the skin along with changes in echogenicity and the presence of vascularity will be checked and compared with the thickness before the injection. The thickness in the dermis, epidermis and subcutaneous tissue is checked and measured. The equipment used for ultrasound is Medison sonoac 8000se at a frequency of 5-9 MHz.. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information