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IRCT20210510051248N1 IRCT 2022-01-22 Shahre-kord University of Medical Sciences Comparison of clinical course of the disease in patients with Covid-19 infection with or without antibiotics Comparison of clinical course of the disease in patients with Covid-19 infection with or without antibiotics 2022-01-21 anticipated 90 Complete https://irct.ir/trial/60668 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are randomized using random allocation software. In the software, the number of groups and the number of samples and groups are determined. Numbers 1 to 90 are then randomly assigned to the control group and the intervention group. Control group : A Intervention group : B, Blinding description: Participants will be divided into control groups (A) and intervention (B) using random allocation software. Envelopes are then prepared according to the number of people participating in the study, and numbers 1 to 90 are written on the envelopes and placed in each envelope using software A and B. In this way, with the arrival of each person, an envelope dedicated to that person is opened and according to the option inside the envelope, the person is assigned to one of the intervention or control groups. 2-3 Covid-19. Intervention 1: Intervention group: Vial Remdesivir 100 mg Ronak Pharmaceutical Company for 5 days, 200 mg on the first day and 100 mg on the second to fifth days; Levofloxacin 750 mg tablets Abidi Pharmaceutical Company for 5 days, 750 mg daily; Vial Ceftriaxone 1 gr Exir Pharmaceutical for 5 days, 1 gr every 12 hours;. Intervention 2: Control group: Vial Remdesivir 100 mg Ronak Pharmaceutical Company for 5 days, the first day 200 mg and the second to fifth days 100 mg. Yes - There is a plan to make this available What will be shared: Information about the main outcome can be shared. When: Access period starts 6 months after the results are published To whom: Dr. ahmad raisi Conditions: The documents can be used after printing the results Where to obtain: The data can be used by referring to the e-mail address How to obtain: Access period starts 6 months after the trsults are published Comments:
public Ahmad Raesi
Hajar Hospital, Parastar Street
Shahrekord Iran (Islamic Republic of) 8816754633 +98 38 3222 0016 raesi.a@skums.ac.ir Shahre-kord University of Medical Sciences scientific Ahmad Raesi
Hajar Hospital, Parastar Street
Shahrekord Iran (Islamic Republic of) 8816754633 +98 38 3222 0016 raesi.a@skums.ac.ir Shahre-kord University of Medical Sciences Iran (Islamic Republic of) Patients with confirmed molecular test (PCR positive) Blood oxygen saturation level SpO2 <93% in room air Patients with moderate pulmonary involvement in radiological studies No need for antibiotics in terms of indicator bacterial infection (PCT negative) 18 years 90 years Both Patient dissatisfaction with participation in the study Need for antibiotics according to the indication of bacterial infection (PCT positive) U07.1 COVID-19, virus identified Treatment - Drugs Treatment - Drugs Intervention group: Vial Remdesivir 100 mg Ronak Pharmaceutical Company for 5 days, 200 mg on the first day and 100 mg on the second to fifth days; Levofloxacin 750 mg tablets Abidi Pharmaceutical Company for 5 days, 750 mg daily; Vial Ceftriaxone 1 gr Exir Pharmaceutical for 5 days, 1 gr every 12 hours; Control group: Vial Remdesivir 100 mg Ronak Pharmaceutical Company for 5 days, the first day 200 mg and the second to fifth days 100 mg Erythrocyte Sedimentation rate. Timepoint: Measurement of erythrocyte sedimentation rate on the first and seventh days. Method of measurement: Measurement of erythrocyte sedimentation rate by the device ESR analyzer semimex. C-reactive protein. Timepoint: Measurement of C-reactive protein on the first and seventh days. Method of measurement: Measurement of C-reactive protein with the device BT-3500 And BT-3000. Ferritin. Timepoint: Measurement of ferritin on the first and seventh day. Method of measurement: Measurement of ferritin with the device Cobas. Shahre-kord University of Medical Sciences Approved 2021-11-16 کمیته اخلاق در پژوهش دانشگاه علوم پزشکی شهرکرد خیابان کاشانی دانشگاه علوم پزشکی شهرکرد Shahrekord Chahar-Mahal-va-Bakhtiari Iran (Islamic Republic of)