IRCT20211212053368N1 IRCT 2021-12-20 Ahvaz University of Medical Sciences TGFB-1 level in breast cancer patients treated with external beam whole breast irradiation versus accelerated partial breast irradiation The comparison of transforming growth factor beta-1 serum levels in early-stage breast cancer patients treated with external beam whole breast irradiation plus boost versus interstitial brachytherapy accelerated partial breast irradiation 2021-12-22 anticipated 20 Complete https://irct.ir/trial/60605 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be assigned into two groups by simple randomization method. Allocation of patients to the study groups will be done by random-numbers table and using computer, and on this basis patients will be included in one of the two treatment groups before starting radiotherapy. The implementation of the random allocation sequence occurs without knowledge of which patient will receive which treatment method. N/A Breast cancer. Intervention 1: Intervention group: external irradiation of the whole breast plus boost (photon or electron) is performed. The prescribed dose to isocenter will be 42.5 Gray in 16 fractions or 50 Gray in 25 fractions or 50.4 Gray in 28 fractions. Intervention 2: Intervention group: accelerated partial breast irradiation is performed by multi-catheter interstitial brachytherapy with high dose rate. The recommended dose is 32 Gray in 8 fractions twice a day with the help of 60 cobalt source. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.