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IRCT20210626051717N1 IRCT 2021-12-29 Islamic Azad University Evaluation effect of use PRF in maxillary sinus bone graft Radiologic evaluation of density and height of maxillary sinus use of CBCT with and without use of PRF and biomaterials(Randomized clinical Trial) 2021-12-22 anticipated 20 Complete https://irct.ir/trial/60491 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization in this study is done by simple randomization method with an individual unit so that at the beginning of each surgery in a patient the word left or right is written on the closed cans and by removing a can randomly and observing the word Right or left It is indicated that the fibrin-rich platelet sample is used in the patient's right sinus lift surgery or in left site and in the opposite side only biomaterials are used. N/A Investigation of height and density of maxillary sinus floor bone on both sides of posterior maxilla. Intervention 1: Intervention group: In this study, patients aged 20-80 years without systemic disease with bilateral partial edentulousness or complete edentulousness whose remaining bone height behind the maxilla is less than 5 mm will be selected. Prior to sinus lift surgery, 20 to 40 mm of blood is collected from the patient's vein in sterile test tubes without anticoagulant and will be immediately centrifuged at 3000 rpm for 10 minutes. . As a result of the activation of the coagulation cascade and the formation of a three-layer fibrin network, including: the top layer of cell-free plasma or PPP, the middle layer of PRF and the bottom layer, which are red blood cells, will be visible in the test tube. The middle layer, or PRF, is cut with scissors from the red blood cell clots and will be used randomly with biomaterials on one side of the sinus space. Intervention 2: Control group: This study is performed as a split mouth, ie in each patient, one side of the sinus lift surgery is performed with PRF intervention and is classified as an intervention group, and on the opposite side, sinus lift surgery without PRF intervention is performed as a control group.In each patient, there is both an intervention group and a control group. On one side of the mouth, which uses PRF, it is placed in the intervention group, and on the opposite side of the mouth, which does not use PRF, it is classified in the control group. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no more information. "
public Rana khalafi
No 143. Beheshti Deadend. Gajar Alley.Hojjati street
Tabriz Iran (Islamic Republic of) 5185737418 +98 41 3281 7829 ranakhalafy@gmail.com Islamic Azad University scientific Rana Khalafi
No 143. Beheshti Dead end. Gajar Alley. Hojjati Street
Tabriz Iran (Islamic Republic of) 5185737418 +98 41 3281 7829 ranakhakafy@gmail.com Islamic Azad University Iran (Islamic Republic of) Patients 20 to 80 years old male and female without systemic disease Bilateral partial edentulousness of posterior part of maxilla or complete edentulousness Maxillary sinus floor bone height below 5 mm 20 years 80 years Both Existence of uncontrolled systemic diseases Use of immunosuppressive drugs and bisphosphonates Head and neck radiotherapy Presence of pathology and inflammatory diseases in maxillary sinus Existence of active periodontal disease behind the maxilla Irregular and chronic smoking Treatment - Surgery Treatment - Surgery Intervention group: In this study, patients aged 20-80 years without systemic disease with bilateral partial edentulousness or complete edentulousness whose remaining bone height behind the maxilla is less than 5 mm will be selected. Prior to sinus lift surgery, 20 to 40 mm of blood is collected from the patient's vein in sterile test tubes without anticoagulant and will be immediately centrifuged at 3000 rpm for 10 minutes. . As a result of the activation of the coagulation cascade and the formation of a three-layer fibrin network, including: the top layer of cell-free plasma or PPP, the middle layer of PRF and the bottom layer, which are red blood cells, will be visible in the test tube. The middle layer, or PRF, is cut with scissors from the red blood cell clots and will be used randomly with biomaterials on one side of the sinus space. Control group: This study is performed as a split mouth, ie in each patient, one side of the sinus lift surgery is performed with PRF intervention and is classified as an intervention group, and on the opposite side, sinus lift surgery without PRF intervention is performed as a control group.In each patient, there is both an intervention group and a control group. On one side of the mouth, which uses PRF, it is placed in the intervention group, and on the opposite side of the mouth, which does not use PRF, it is classified in the control group. Using and not using fibrin-rich platelets with biomaterial. Timepoint: 6 months after graft. Method of measurement: Is an independent variable that is measured in terms of use or non-use. Maxillary sinus floor bone density. Timepoint: 6 months after graft. Method of measurement: Hansfield number from CBCT. Height of maxillary sinus floor bone. Timepoint: 6 months after graft. Method of measurement: Based on millimeters from CBCT. Islamic Azad University Approved 2021-12-18 Ethics Committee of Azad University of Medical Sciences, Tabriz Branch Complex No. 2 of Islamic Azad University, Tabriz Branch. medical School .First Basmanj Road.Ahar three ways Tabriz East Azarbaijan Iran (Islamic Republic of)