IRCT20211125053175N1 IRCT 2022-01-29 Kerman University of Medical Sciences Evaluating effectiveness of therapy with topical isoniazid in melasma Comparison of the Efficacy of topical isoniazid versus placebo in the treatment of patients with melasma in a randomized double-blind clinical trial 2022-02-20 anticipated 20 Complete https://irct.ir/trial/60359 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: For randomization, a list of random numbers was created using Excel software that determined the patients in treatment groups. In this method, the presence of patients in groups was based on the inclusion in the study after obtaining informed consent. In this study, opaque sealed plates were used to conceal random allocation, so that it is not possible to guess the allocation of each patient to the treatment group until the envelope is opened, Blinding description: This is a double-blind study for patients and data analyzor . both drugs were kept in identical plastic containers,so the evaluating physician and patient didn't know about their containings. 2-3 melasma. Intervention 1: Intervention group:Isonicotinic acid hydrazide cream 10%. How to use: Topical use, once daily. Duration of treatment: 12 weeks. Manufacturing factory: Exir, Iran. Intervention 2: Control group: Intervention group: Cold cream. How to use: Topical use, every night. Duration of treatment: 12 weeks. Manufacturing factory:Gol daroo Pharmaceutical Factory. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is because it is not necessary