IRCT20150101020514N13 IRCT 2021-12-13 Jarf Andishan Nnavid Salamat knowlage based company (JANUS) Safety and efficacy comparison of gel and emulgel formulations of Tertinoin and Clindamaycin for treatment of mild to moderate acne vulgaris Safety and efficacy comparison of gel and emulgel formulations of tretinoin 0.025% and clindamaycin 1.2% for treatment of mild to moderate acne vulgaris 2021-12-22 anticipated 20 Complete https://irct.ir/trial/60267 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization is done simply using a blind card, so names of the formulations are written on the same cards then each card is randomly selected for any side of the face, Blinding description: Products of both groups are packed in similar boxes with different numeric code. In case of assessor blinding, the randomization list is given to a third person. The clinicians who performed the clinical assessments and objective device analysis are completely blinded to the treatment type. participants will receive the treatment according to the randomization list by an independent assistant. 2 Acne vulgaris. Intervention 1: Intervention group: Topical application of compounding emulgel (not industrial) containing tretinoin 0.025% and clindamaycin 1.2% on acne lesions of one side of the face (randomly) once a day (before sleeping), for 8 weeks. Intervention 2: Control group: Topical application of compounding gel (not industrial) containing tretinoin 0.025% and clindamaycin 1.2% on acne lesions of one side of the face (randomly) once a day (before sleeping), for 8 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information