IRCT20141001019359N11 IRCT 2022-01-09 Bojnourd University of Medical Sciences Pregabalin and Paracetamol effect on pain after Laparoscopic cholecystectomy تاثیر پرگابالین-پاراستامول بر درد شانه The effect of pregabalin-paracetamol on shoulder pain in patients after laparoscopic cholecystectomy, Double-blind controlled randomized trial 2021-12-22 anticipated 90 Complete https://irct.ir/trial/60238 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Sampling in this study will be that first in order to enter the study patients will be in the form of non-random sampling of the type "available" and then divide them into three intervention groups by randomly assigned blocking using a web-based system. Random blocking at www.randomization.com will be done in 15 blocks of 6. So that in each block, there are 2 people in the first group (A), two people in the second group (B) and two people in the third group (C). After a random sequence was identified in all blocks, cards were written by writing C, B, and A to indicate which group each patient was assigned to, and by someone other than the research team from 1 to 90 in all blocks, respectively. They are numbered and these cards are placed in sealed non-transparent envelopes, respectively. Then, in order to hide the random allocation, when the patient visits, the opaque sealed envelope will be opened and then one by one, it will be determined for each sample of the relevant group, Blinding description: None of the participants in the study will be aware of the randomization list and also to apply allocation concealment randomization, the groups are placed in closed envelopes in the admission section and eligible individuals who enter the study are included respectively.Therefore, the study was double-blind so that patients and outcome evaluation specialist are unaware of the allocation status of the three groups to the study. 3 pain. Intervention 1: Intervention group: Administration One hour before surgery, a single dose of pregabalin 300 mg orally. And 30 minutes before the end of surgery Paracetamol 1 gr per 100cc of normal saline 0.9% diluted are given as an infusion. Also they will receive 1 gr Paracetamol per 100 cc N/S 0.9% diluted as an infusion per 6 to 24 hours after surgery. Intervention 2: Intervention group: Administration a single dose of pregabalin 300 mg orally, One hour before surgery. Intervention 3: Control group: Administration of placebo, One hour before surgery. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information