IRCT20211105052972N1 IRCT 2021-12-04 Mashhad University of Medical Sciences Effects of tolerable high dose of Vitamin B12, B6 & Folate intake on Behavioral and psychological symptoms & Quality of life in patients with Alzheimer's disease Effects of tolerable high dose of Vitamin B12, B6 & Folate intake on Behavioral and psychological symptoms & Quality of life in patients with Alzheimer's disease 2021-12-21 anticipated 60 Complete https://irct.ir/trial/59806 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: A total number of 60 Alzheimer’s type dementia eligible according to the included criteria and filled the informed consent (themselves or a family member) randomly divided into two interventions (n=30) and a control group (n=30) with Block randomization of two treatment groups A and B, number of blocks = 6, size of blocks = 10, and fixed-size blocks. C the Sequentially numbered, opaque, sealed envelope (SNOSE) technique is for Concealment of allocation. sealed envelopes are the randomization tools, Blinding description: All drugs (placebo and intervention) in both groups are double-blinded and similar in color, size, and shape. neither the participant nor the investigator, caregivers, data collectors, and outcome assessor is aware of the treatment allotted. N/A Alzheimer’s disease with late onset: Onset usually after the age of 65. Intervention 1: Intervention group (n=30): each patient takes 3 tablets daily from their caregivers ( 40 mg Tablet of Vitamin B6, 1mg tablet of Vitamin B9, and 1mg tablet of Vitamin B12) after the meal with a glass of water for two months. according to ethical problems, In the intervention and control groups, patients receive similar standard main AD medicines. Intervention 2: Control group (n=30): each patient takes 3 placebo tablets from their caregivers daily (shape, size, and color-matched with the case group) right after the meal with a glass of water for 2 months. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information