]>
IRCT20141209020258N169 IRCT 2021-11-06 Arak University of Medical Sciences Comparison of the effect of low-dose amiodarone alone and its combination with ‎magnesium in the control of atrial fibrillation after coronary artery bypass graft Comparison of the effect of low-dose amiodarone alone and its combination with ‎magnesium in the control of atrial fibrillation after coronary artery bypass graft 2021-11-22 anticipated 208 Complete https://irct.ir/trial/59783 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be allocated into 2 groups using a permuted balanced block randomization method with the size of blocks 2 and 4. Random sequence will be generated by an epidemiologist by running an online program in sealed envelope website (https://www.sealedenvelope.com/). Random chain concealment is done by opaque envelope method, Blinding description: It is a double-blind study. Analysts, evaluators, and participants are unaware of the consequences of grouping.The intern is unaware of the drugs prescribed in each group and the anesthesiologist prepares the drugs and provides them to the intern, and the patients are not aware of their group. 3 Coronary artery bypass graft. Intervention 1: Intervention group 1: 300 milligram of Amiodarone is placed on the syringe pump, which is infused for the patient in 20 minutes, and 2 grams of magnesium sulfate will be slowly injected for the patients. Intervention 2: Intervention group 2: We will provide only 300 milligram of Amiodarone in the form of infusion for patients. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Dr Alireza Rostami
Amiralmomenin Hospital, Sardasht
Arak Iran (Islamic Republic of) 3814957558 +98 86 3222 2003 alikamaliir@yahoo.com Arak University of Medical Sciences scientific Dr Alireza Kamali
Valiasr Hospital, Valiasr squre, Shahid Shirodi street
Arak Iran (Islamic Republic of) 3814957558 +98 68 3222 2003 alikamaliir@yahoo.com Arak University of Medical Sciences Iran (Islamic Republic of) All patients are candidates for coronary artery bypass graft surgery Their surgery is ON Pump Absence of emergency coronary artery bypass graft surgery Lack of valve repair and replacement surgery Insensitivity to Amiodarone and Magnesium 18 years no limit Both Patients who suffer from cardio-respiratory arrest during surgery and die during surgery. Patients who go to the cardiopulmonary pump more than once for any reason. I25.709 Atherosclerosis of coronary artery bypass graft(s), unspecified, with unspecified angina pectoris Treatment - Drugs Treatment - Drugs Intervention group 1: 300 milligram of Amiodarone is placed on the syringe pump, which is infused for the patient in 20 minutes, and 2 grams of magnesium sulfate will be slowly injected for the patients. Intervention group 2: We will provide only 300 milligram of Amiodarone in the form of infusion for patients. Duration of hospitalization in the intensive care unit. Timepoint: In duration study. Method of measurement: Patient file. Incidence of atrial fibrillation. Timepoint: From the beginning of the intervention until 72 hours after the operation. Method of measurement: Physical examination. Mortality rate. Timepoint: During the study. Method of measurement: Patient file. Arak University of Medical Sciences Approved 2021-08-29 Ethics comittee of Arak University of Medical Sciences Ethics comittee, Research center, Payambar Azam complex, Basij squre ,Sardasht,Arak Arak Markazi Iran (Islamic Republic of)