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IRCT20170404033202N9 IRCT 2022-03-12 Sabzevar University of Medical Sciences Monitoring and comparison of fluctuations in blood oxygen saturation in two methods of induction of anesthesia by priming and succinylcholine in patients undergoing appendectomy Monitoring and comparison of fluctuations in blood oxygen saturation in two methods of induction of anesthesia by priming and succinylcholine in patients undergoing appendectomy 2021-11-21 anticipated 50 Complete https://irct.ir/trial/59695 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be selected at random using the most available people for the study. Each person was given a code A or B at random (sheet or envelope) and treatment was performed based on it (group A was intervention and group B was control), Blinding description: This study will be performed as a two-way blind, in which the patient and the evaluating physician are blinded to the patient group so that the patient knows the plan but does not know in which group and the physician recording the variables does not know the patient group. Depending on whether the patient is in group A (intervention) or B (control), the drugs are different. 3 Comparison of fluctuations in blood oxygen levels in two methods of induction of anesthesia by priming and succinylcholine. Intervention 1: Intervention group: The group receiving succinylcholine for anesthesia.Intervention group: The group receiving succinylcholine for anesthesia in this study in both groups 0.02 mg / kg midarolam and 2 μg / kg fentanyl was given as a premedication and after three minutes in group A5 5 mg / kg sodium Thiopental is given and then scolin is given at a dose of 1.5 mg / kg and after 30 seconds the patient is intubated and then atracurium 0.5 mg / kg is administered in both groups of anesthesia with isoflurane at a dose of 2.1%. And every 45 minutes fentanyl at a dose of 1 μg / kg and atracurium at 30% of the initial dose will be repeated every 30 minutes. Intervention 2: Control group: In this study, in both groups, 0.02 mg / kg midarolam and 2 μg / kg fentanyl were given as pre-medication and after three minutes in group B (control) after pre-medication, 10% dose of atracurium (half mg). / Kg) is prescribed for 4 minutes sodium thio pental at a rate of 5 ml / kg and the rest of the atracorium is administered and after 60 to 90 seconds of intubation is performed in both groups of anesthesia with isoflurane at a dose of 1/2 Will be and every 45 minutes fentanyl at a dose of 1 microgram / kg and atracurium will be repeated every 30 minutes at a rate of one third of the initial dose. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Mohammad Nematshahi
Asadabadi Central Organization of the University
Sabzevar Iran (Islamic Republic of) 9613885697 +98 51 4422 9081 9151737407mn@gmail.com Sabzevar University of Medical Sciences scientific Mohammad Nematshahi
Asadabadi Central Organization of the University
Sabzevar Iran (Islamic Republic of) 9613885697 +98 51 4422 9081 9151737407mn@gmail.com Sabzevar University of Medical Sciences Iran (Islamic Republic of) Diagnosed and designated appendicitis and a candidate for appendectomy consent to participate in the evaluation between the ages of 20 and 60 years with ASA class 1 and 2 20 years 60 years Both Reluctance to study Patients under 20 years and over 60 years Patients with ASA grade equal to or greater than 3 Patients with advanced heart and lung problems Treatment - Drugs Treatment - Drugs Intervention group: The group receiving succinylcholine for anesthesia.Intervention group: The group receiving succinylcholine for anesthesia in this study in both groups 0.02 mg / kg midarolam and 2 μg / kg fentanyl was given as a premedication and after three minutes in group A5 5 mg / kg sodium Thiopental is given and then scolin is given at a dose of 1.5 mg / kg and after 30 seconds the patient is intubated and then atracurium 0.5 mg / kg is administered in both groups of anesthesia with isoflurane at a dose of 2.1%. And every 45 minutes fentanyl at a dose of 1 μg / kg and atracurium at 30% of the initial dose will be repeated every 30 minutes. Control group: In this study, in both groups, 0.02 mg / kg midarolam and 2 μg / kg fentanyl were given as pre-medication and after three minutes in group B (control) after pre-medication, 10% dose of atracurium (half mg). / Kg) is prescribed for 4 minutes sodium thio pental at a rate of 5 ml / kg and the rest of the atracorium is administered and after 60 to 90 seconds of intubation is performed in both groups of anesthesia with isoflurane at a dose of 1/2 Will be and every 45 minutes fentanyl at a dose of 1 microgram / kg and atracurium will be repeated every 30 minutes at a rate of one third of the initial dose Measurement of blood oxygen. Timepoint: Before treatment and immediately after surgery, recovery is recorded at intervals of 10 minutes to 3 times until transfer to the ward. Method of measurement: check list. Sabzevar University of Medical Sciences Approved 2022-02-08 Ethics committee of Sabzevar University of Medical Sciences Campus of University of Medical Sciences Sabzevar Razavi Khorasan Iran (Islamic Republic of)