IRCT20211024052857N1 IRCT 2021-11-08 Karaj University of Medical Sciences The effects of probiotics administration on acute side effects of chemotherapy regimens in gastroesophageal cancer patients The effects of probiotics administration on acute side effects of chemotherapy regimens in gastroesophageal cancer patients 2021-11-26 anticipated 42 Complete https://irct.ir/trial/59630 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Participants were randomly assigned to receive either probiotic (n = 21) or nothing (control = 21) based on randomized block randomization and stratified randomization. Closed pockets were used to hide the randomization process, which was opened at the time of the patient's visit to minimize the gap between randomization and drug or control, Blinding description: Randomization and allocation will be concealed from the researchers and participants until the final analyses will be completed. Another person who is not involved in the trial and not aware of random sequences, will be assigned the participants to the numbered pockets of capsules. 3 Gastroesophageal cancers. Intervention 1: Intervention group: Patients will be given probiotics (" DailyEast", Zist Takhmir ) once a daily during their chemotherapy. Intervention 2: Control group: Patients will be given their standard drugs during chemotherapy. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information is available.