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IRCT20210915052494N1 IRCT 2021-11-04 Shiraz University of Medical Sciences Effect of Vitamin B6 and L-acetyl-carnitin in Treatment of Carpal Tunnel Syndrome CTS Investigation of the Effect of Vitamin B6 Supplement in Comparison to L-acetyl-carnitine on Improvement of Patients with Carpal Tunnel Syndrome 2021-11-06 anticipated 60 Complete https://irct.ir/trial/59488 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Block permutation with 4 samples in each block will be used. 2 final lists with using random allocation software will be made. For allocation concealment, randomized sequence is given to an uninformed person (etc; clinic secretary), Blinding description: The person who fills the questionnaires and static analyzer are blind. 3 Carpal tunnel syndrome. Intervention 1: First intervention group: 120 mg Vitamin B6 Janilous pharmaceutical Co. daily and splint for 10 weeks. Intervention 2: Second intervention group: 1500 mg L-acetyl-carnitine Dana pharmaceutical Co. daily and splint for 10 weeks. Yes - There is a plan to make this available What will be shared: All the data will be shared after masking the identity of participants When: The information will be available 3 months after print To whom: All the researchers and physicians Conditions: Only for research purposes Where to obtain: dr.parsanavid@gmail.com Navid Parsa How to obtain: After receiving the email, information will be given in less than one week. Comments:
public Navid Parsa
No. 50, Golestan 4th alley, Nahid Ave, Marzdaran
Tehran Iran (Islamic Republic of) 1461643744 +98 21 2201 9258 dr.parsanavid@gmail.com Shiraz University of Medical Sciences scientific Navid Parsa
No. 50, Golestan 4th alley, Nahid Ave, Marzdaran
Tehran Iran (Islamic Republic of) 1461643744 +98 21 2201 9258 dr.parsanavid@gmail.com Shiraz University of Medical Sciences Iran (Islamic Republic of) Patients with Mild or Moderate Carpal Tunnel Syndrome Disease Proved with Electrodiagnostic Study within Last 2 Months Patients Age Ranges from 30-60 30 years 60 years Both Severe Carpal Tunnel Syndrome Muscle Atrophy History of Carpal Tunnel Syndrome surgery History of Trauma History of Fracture History of Direct Injection of Carpal Tunnel History of Recent Usage of Corticosteroids and Analgesics Diabetes Collagen Vascular Disorders Rheumatologic Disorders Active Radiculopathy Past Medical History of Brucellosis Pregnancy Lactation Alcoholism Nerve Injury Neuropathy Inability in Communication and Fulfilling Questioners History of Allergic Reaction to Studied Medications History of Significant Liver, Kidney or Cardiovascular Disease Cancer History of Injection Around Wrist within 3 Last Months Treatment - Drugs Treatment - Drugs First intervention group: 120 mg Vitamin B6 Janilous pharmaceutical Co. daily and splint for 10 weeks Second intervention group: 1500 mg L-acetyl-carnitine Dana pharmaceutical Co. daily and splint for 10 weeks Latency of Median sensory nerve action potential. Timepoint: Before the treatment, 10 and 18 weeks after beginning treatment. Method of measurement: Electromyography-Nerve conduction study (EMG-NCV) machine. Score of clinical symptoms (like pain and paresthesia) in questionnaires. Timepoint: Before the treatment, 10 and 18 weeks after beginning treatment. Method of measurement: Visual Analogous Scale and Boston Carpal Tunnel Questionnaire. Shiraz University of Medical Sciences Approved 2021-06-14 Ethics committee of Shiraz University of Medical Sciences Physical medicine and rehabilitation Department, Faghihi hospital, Zand Blvd Shiraz Fars Iran (Islamic Republic of)