IRCT20211015052778N1 IRCT 2022-05-11 Boushehr University of Medical Sciences Evaluation of phototherapy on premature neonates Comparison of the effect of prophylactic phototherapy with therapeutic phototherapy on serum bilirubin and neurodevelopment in 1500-2000-gr preterm neonates 2022-06-22 anticipated 200 Complete https://irct.ir/trial/59423 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Infants with ≤1500-2000 gr will be randomly divided into two groups. Random allocation was performed using R software and the resulting random design will be placed in special envelopes. Infants who meet the required criteria will be assigned to the intervention group (A) and the control group (B) consecutively. The random allocation file is attached in the appendices section. The intervening physician will not be aware of the random allocation scheme and the number of blocks, Blinding description: Study participants do not know whether they are in the control or the intervention group. N/A Hyperbilirubinemia. Intervention 1: Intervention group: infants will receive prophylactic phototherapy in the first 24 hours after birth. Phototherapy will be performed using a 5-DTA-lamp portable Phototherapy Equipment - XHZ-90P with Philips lamps in Shohadaye Khalije Fars Hospital and using Tucson phototherapy device with Philips lamps in Social Security Hospital (Salman Farsi Hospital). Intervention 2: Control group: receive no prophylaxis, and infants will receive theraputic phototherapy after bilirubin rise according to the curves in Nelson's book. No - There is not a plan to make this available Justification or reason for not sharing IPD is Due to possible use by ourselves for future projects