]>
IRCT20211012052735N1 IRCT 2021-11-05 Shahre-kord University of Medical Sciences Effect of Methylene Blue in treatment of Coronavirus Patients Investigation the Effects of Methylene Blue on Coronavirus Patients treatment 2021-11-11 anticipated 60 Complete https://irct.ir/trial/59256 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization method: simple randomization randomization unit: individualized randomization tool: through the randomization website https://random.org/lists/. Simple randomization will be achieved through numbers randomly generated by the website, in a way that according to the generated list, the target individuals will be randomly divided into two groups of control and treatment (by Methylene blue), Blinding description: Patients, Researchers, Health personnel, data collectors, and those evaluating the outcome will be blinded throughout this study. 1-2 coronavirus infection. Intervention 1: In this clinical trial study, 60 patients with Covid-19 admitted to Hajar Hospital in Shahrekord with positive PCR test and O2-Saturation equal to 85 and less are selected and randomly divided into two groups of 30. Control and Intervention. Treated group: O2-Saturation equal to 85 and less. All the 30 patients will be matched in terms of age and gender. Prior to the study, all patients will be tested for biochemical factors such as CRP, methemoglobin, ferritin, serum creatinine, SGOT, SGPT, and LDH, Ddimer, CRP, and O2-Saturation levels will be measured daily. For patients in the treatment group, methylene blue (at the time of hospitalization) with a concentration of 34 mg / kg is given for 4 days, orally, along with the conventional treatments (routine treatment), Remdesiver and corticosteroids. At the end of four days, patients are assessed for improvement in indicators (general condition, O2-Saturation level, and biochemical factors) compared to the control group. Intervention 2: In this clinical trial study, 60 patients with Covid 19 admitted to Hajar Hospital in Shahrekord with positive PCR test and O2-Saturation equal to 85 and less are selected and randomly divided into two groups of 30. Control group:O2-Saturation equal to 85 and less. The 30 patients in both groups will be matched in terms of age and gender. Prior to the study, all patients will be tested for biochemical factors such as CRP, methemoglobin, ferritin, serum creatinine, SGOT, SGPT, and LDH, Ddimer, CRP, and O2-Saturation levels are measured daily. The control group will only receive the usual treatment (routine treatment) of Remdesiver and corticosteroids with placebo. At the end of four days, patients are assessed for improvement in indicators (general condition, O2-Saturation level, and biochemical factors). Yes - There is a plan to make this available What will be shared: All data will be shared When: 6 months after the results are published To whom: Researchers working in academic and scientific institutions Conditions: Provide other scientific research Where to obtain: Dr Akbar Soleimani How to obtain: By E-mail Comments:
public Dr Akbar Soleimani
Rahmatyeh
Shahrekord Iran (Islamic Republic of) 8813833435 +98 35 3333 1471 j_saffari@yahoo.com Shahre-kord University of Medical Sciences scientific Dr. Akbar Soleimani
Rahmatyeh
Shahrekord Iran (Islamic Republic of) 8813833435 +98 38 3333 1471 j_saffari@yahoo.com Shahre-kord University of Medical Sciences Iran (Islamic Republic of) Patients are to be free of any underlying disorders. Patients are to be free of any kidney (creatinine test), liver (liver and LFT tests), and heart damages. The age of inclusion in the study is to be between 20-50 years Nasopharyngeal RT-PCR test sample is to be positive Diagnosed with lung damages through CT scan Have no history of viral infections with hepatitis and AIDS Have not had received recombinant treatments Have not had G6PD enzyme defect O2Saturation of patients is to be less or equal to 85 20 years 50 years Both Pregnant women and women who are planning to become pregnant Breastfeeding women People with a history of allergies to methylene blue People with a BMI above 30 People with kidney, heart, lung disorders B34.2 Coronavirus infection, unspecified Treatment - Drugs Placebo In this clinical trial study, 60 patients with Covid-19 admitted to Hajar Hospital in Shahrekord with positive PCR test and O2-Saturation equal to 85 and less are selected and randomly divided into two groups of 30. Control and Intervention. Treated group: O2-Saturation equal to 85 and less. All the 30 patients will be matched in terms of age and gender. Prior to the study, all patients will be tested for biochemical factors such as CRP, methemoglobin, ferritin, serum creatinine, SGOT, SGPT, and LDH, Ddimer, CRP, and O2-Saturation levels will be measured daily. For patients in the treatment group, methylene blue (at the time of hospitalization) with a concentration of 34 mg / kg is given for 4 days, orally, along with the conventional treatments (routine treatment), Remdesiver and corticosteroids. At the end of four days, patients are assessed for improvement in indicators (general condition, O2-Saturation level, and biochemical factors) compared to the control group. In this clinical trial study, 60 patients with Covid 19 admitted to Hajar Hospital in Shahrekord with positive PCR test and O2-Saturation equal to 85 and less are selected and randomly divided into two groups of 30. Control group:O2-Saturation equal to 85 and less. The 30 patients in both groups will be matched in terms of age and gender. Prior to the study, all patients will be tested for biochemical factors such as CRP, methemoglobin, ferritin, serum creatinine, SGOT, SGPT, and LDH, Ddimer, CRP, and O2-Saturation levels are measured daily. The control group will only receive the usual treatment (routine treatment) of Remdesiver and corticosteroids with placebo. At the end of four days, patients are assessed for improvement in indicators (general condition, O2-Saturation level, and biochemical factors). Blood O2 saturation. Timepoint: daily. Method of measurement: saturation %. Shahre-kord University of Medical Sciences Approved 2021-08-14 IR.SKUMS.REC.1400.111 Rahmatyeh Shahrekord Chahar-Mahal-va-Bakhtiari Iran (Islamic Republic of)