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IRCT20150713023190N10 IRCT 2021-10-24 Rafsanjan University of Medical Sciences Effect of Cuminum Cyminum on the return of intestinal peristaltic movements after abdominal surgeries Investigating the effect of Cuminum Cyminum on the return of intestinal peristaltic movements after abdominal surgeries in patients who hospitalized in the surgery ward of Ali Ibn Abi Taleb Hospital of Rafsanjan, 2021 2021-10-23 anticipated 70 Complete https://irct.ir/trial/59216 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Stratified randomization by minimization method: in this method, initially, the patients will categorize based on key variables, such as type of surgery and gender. Afterwards, from the patients who will meet the inclusion criteria, the first participant will place in the intervention or control group by coin flip, and other participants will allocate to the study group with lower total of variables, Blinding description: The patient will not know that he/she is in the intervention group or control. The capsules will be prepared by pharmacist and the researcher will not be aware of the capsules. The analyzer will not know the intervention and control groups. 2-3 Return of intestinal peristaltic movements. Intervention 1: Intervention group: In this group, patients receive a 250 mg capsule of Cuminum Cyminum extract 4 hours after surgery and one hour after the first dose of this drug. Intervention 2: Control group: In this group, patients will receive placebo (a 250 mg capsule of starch) exactly like the intervention group. No - There is not a plan to make this available Justification or reason for not sharing IPD is Confidentiality of data
public Amin Esmaeili Abdar
Parastar Ave
Rafsanjan Iran (Islamic Republic of) 7718796755 +98 34 3425 5900 amin31401@gmail.com Rafsanjan University of Medical Sciences scientific Tabandeh Sadeghi
Parastar Ave
Rafsanjan Iran (Islamic Republic of) 7718796755 +98 34 3425 5900 t.b_sadeghi@yahoo.com Rafsanjan University of Medical Sciences Iran (Islamic Republic of) Age between 18-60 years Candidate for abdominal surgery General anesthesia Inform consent for participate in the study 18 years 60 years Both Use of Cuminum Cyminum permanently pregnancy and lactation Addiction Use of alcohol History of liver, kidney, heart and thyroid disorders Use of anticoagulant drugs Use of psychiatric drugs Gastric perforation R19.11 Absent bowel sounds Treatment - Other Placebo Intervention group: In this group, patients receive a 250 mg capsule of Cuminum Cyminum extract 4 hours after surgery and one hour after the first dose of this drug. Control group: In this group, patients will receive placebo (a 250 mg capsule of starch) exactly like the intervention group. First gas passing. Timepoint: After the intervention. Method of measurement: Checklist (patient’ response will be recorded in the checklist). First defecation. Timepoint: After the intervention. Method of measurement: Checklist. Abdominal bloating. Timepoint: 2 hour after the intervention until 24 hours. Method of measurement: Checklist. Abdominal pain. Timepoint: 2 hour after the intervention until 24 hours. Method of measurement: Checklist. Nausea. Timepoint: 2 hour after the intervention until 24 hours. Method of measurement: Checklist. Vomiting. Timepoint: 2 hour after the intervention until 24 hours. Method of measurement: Checklist. Rafsanjan University of Medical Sciences Approved 2021-10-02 Ethics committee of Rafsanjan University of Medical Sciences Imam Ali Blvd Rafsanjan Kerman Iran (Islamic Republic of)