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IRCT20160703028756N7 IRCT 2021-10-16 Esfahan University of Medical Sciences The effect of intrauterine injection of human chorionic gonadotropin before embryo transfer on pregnancy outcomes in assisted reproductive cycles Evaluation of the effect of intrauterine injection of human chorionic gonadotropin (HCG) before embryo transfer (ET) on pregnancy outcomes in assisted reproductive cycles (IVF / ICSI) 2021-08-29 anticipated 100 Complete https://irct.ir/trial/59106 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: After the approval of the ethics committee and performing PCRcovid19 test (due to the unknown nature of Covid virus and its possible effects on fertility results and IVF cycles) from all patients before entering the operating room for embryo transfer "and in case of negative Covid PCR test" women were randomly divided Both groups are assimilated in terms of "BMI" AMH. Speculum is injected and is not injected in the control group, Blinding description: The drug will be injected in the case group by an infertility specialist and in these cases the patient is unaware of which group he is in, given that the injection is given intrauterine and in a lithotomy position and the patient feels pain during the injection. Will not notice this process, on the other hand, after the embryologist injection, the fetus will be transferred while the patient is in the control group or is unaware of the case. 2 Infertility. Intervention group: In the intervention group, a 5000-unit vial of Karma brand with Karma brand is mixed with 0.4 ml of embryo glue and 40 μl of which is equivalent to 500 units of HCG is injected into the uterus through an IUI catheter within 15 minutes before transfer to the erectile position and injected into the orthopedic position.. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Elham Naghshineh
Felezzy bridge, Motahhari street, Shahid Beheshti hospital
Esfahan Iran (Islamic Republic of) 8184853542 +98 31 3236 2191 naghshineh@med.mui.ac.ir Esfahan University of Medical Sciences scientific Elham Naghshineh
Felezzy bridge, Motahhari street, Beheshti hospital
Esfahan Iran (Islamic Republic of) 8184853542 +98 31 3236 2191 naghshineh@med.mui.ac.ir Iran University of Medical Sciences Iran (Islamic Republic of) Hip women under the age of 40 who have undergone IVF / ICSI treatment protocols are endocrine candidates for grade A or B embryos. 20 years 40 years Female Azoospermia through sperm testing History of uterine surgery through history Severe endometriosis through history and ultrasound findings Hydrosalpinx by ultrasound or hysterosalpingography Endocrine disorders such as diabetes thyroid via blood biochemistry test History of operative hysteroscopy History of recurrent miscarriages More repeated failures equal to 3 times in the history Treatment - Drugs Intervention group: In the intervention group, a 5000-unit vial of Karma brand with Karma brand is mixed with 0.4 ml of embryo glue and 40 μl of which is equivalent to 500 units of HCG is injected into the uterus through an IUI catheter within 15 minutes before transfer to the erectile position and injected into the orthopedic position. Follicle size. Timepoint: During embryo transfer and one week after embryo transfer. Method of measurement: sonography. Type of embryo transferred. Timepoint: ---. Method of measurement: --. Number of embryos transferred per cycle. Timepoint: Patient cycle. Method of measurement: Laboratory. AMH. Timepoint: Before embryo transfer. Method of measurement: Laboratory. Ongoing pregnancy. Timepoint: After embryo transfer. Method of measurement: Question from the patient. Cilinical pregnancy. Timepoint: After embryo transfer. Method of measurement: Question from the patient. Chemical pregnancy. Timepoint: After embryo transfer. Method of measurement: Question from the patient. Esfahan University of Medical Sciences Approved 2021-08-29 Ethics Committee of Isfahan University of Medical Sciences Hezar Jarib St., Isfahan University of Medical Sciences and Health Services Esfahan Isfehan Iran (Islamic Republic of)