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IRCT20210101049905N2 IRCT 2021-11-22 Hamedan University of Medical Sciences Effect of Clcitriol in Ischemi stroke Comparison between calcitriol and placebo on serum interleukin 6 level, stroke severity, infarct volume and clinical outcomes in patients with ischemic stroke 2021-11-11 anticipated 78 Complete https://irct.ir/trial/59098 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: Patients are randomly divided into intervention and control groups. The allocation of patients in the control and intervention groups is a random block, so that we put 2 sheets A and two sheets B in an envelope, and each time we remove one of the sheets, we place the patient in the control or intervention group, Blinding description: Patients are randomly divided into intervention and control groups. The allocation of patients in the control and intervention groups is through random block method, so that we put 2 sheets A and two sheets B in an envelope, and each time we remove one of the sheets and determine the group for the patient. The sheet is taken out and will not be returned to the envelope until the sheets in the envelope will be finished. 2 Ischemic Stroke. Intervention 1: Intervention group: In this group, in addition to the standard treatment, Dana Company's oral calcitriol is prescribed to patients at the dose of 1 microgram once a day for 5 days. Intervention 2: Control group: In the control group, patients receive aqueous placebo solution produced by Dana company in addition to the standard treatment. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Mahdi Mahanpoor
No. 3873, Lale deadend, Olke alley, Imam Khomeini street
Arak Iran (Islamic Republic of) 3813783873 +98 86 3224 2129 mahdymahanpoor@yahoo.com Hamedan University of Medical Sciences scientific Mahdi Mahanpoor
No. 3873, Lale deadend, Olke alley, Imam Khomeini street
Arak Iran (Islamic Republic of) 3813783873 +98 86 3224 2129 mahdymahanpoor19@yahoo.com Hamedan University of Medical Sciences Iran (Islamic Republic of) Age 18 to 85 years Focal neurological disorder Clinical diagnosis of acute ischemic stroke Radiological findings of MRI and CT are consistent with the clinical diagnosis of acute hemisphere stroke Patients who have been hospitalized for the first 24 hours after a stroke. Patients suffering from ischemic stroke for the first time 18 years 85 years Both Evidence based on acute or chronic intracerebral hemorrhage and cerebral aneurysm Existence of any etiology other than ischemia Existence of any cognitive or behavioral disorders that lead to the patient not cooperating. Consumption of any combination or drug with antioxidant effects except prescription drugs Existence of another concomitant inflammatory disease Taking medications other than standard ischemic stroke treatments that alter the levels of the factors under consideration. Pregnancy and lactation Use any combination with antioxidant and anti-inflammatory effects in the past month Asthma and a history of anaphylactic shock Taking drugs that interfere with calcitriol I63.00 Cerebral infarction due to thrombosis of unspecified precerebral artery Treatment - Drugs Placebo Intervention group: In this group, in addition to the standard treatment, Dana Company's oral calcitriol is prescribed to patients at the dose of 1 microgram once a day for 5 days. Control group: In the control group, patients receive aqueous placebo solution produced by Dana company in addition to the standard treatment Interleukin 6. Timepoint: At the beginning of the study and 3 days after the end of the medication. Method of measurement: ELISA test. National Institutes of Health Stroke Scale score. Timepoint: At the beginning of the study and 90 days after the end of the medication. Method of measurement: NIHSS questionnaire. Vice Chancellor for Research and Technology of Hamadan University of Medical Sciences Approved 2021-07-10 Ethics Committee of Hamadan University of Medical Sciences Research Ethics Committee, Vice Chancellor for Research and Technology, Hamadan University of Medical Sciences, Shahid Fahmideh Blvd., Hamedan Hamadan Iran (Islamic Republic of)