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IRCT20101130005280N42 IRCT 2021-09-27 Mashhad University of Medical Sciences The effect of amphotericin B on sinusitis Evaluation the efficacy of non-liposomal amphotericin B in the treatment of chronic sinusitis 2021-10-07 anticipated 80 Complete https://irct.ir/trial/58895 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: Simple randomization with table of random numbers available at ''www.randomization.com'' website will be used. Numbers will be placed in sealed envelopes and each envelope is assigned to one participant placing them in one of the two groups, Blinding description: The subjects and those evaluating the outcome will be unaware of the intervention and control groups. 2-3 Chronic sinusitis and polyposis. Intervention 1: Intervention group: In this group, 40 patients, in addition to routine treatment, use amphotericin B solution for rinsing the nose twice a day for a month. Intervention 2: Control group: In this group, in addition to routine treatment, 40 patients use normal saline solution for rinsing the nose twice a day for a month. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is After finishing work, consult with colleagues and it will be published if all members
public Mohammadreza Majidi
Ghaem Hospital, Ahmad Abad AVE
Mashhad Iran (Islamic Republic of) 99199-91766 +98 51 3841 3492 majidimr@mums.ac.ir Mashhad University of Medical Sciences scientific Mohammadreza Majidi
Ghaem Hospital, Ahmad Abad AVE
Mashhad Iran (Islamic Republic of) 99199-91766 +98 51 3841 3492 majidimr@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Chronic sinusitis with polyposis Candidate for sinus endoscopy surgery Conscious consent to participate in the study 18 years 50 years Both Co-occurrence of systemic diseases such as diabetes, chronic renal failure, malignancies, cystic fibrosis, or granulomatous diseases Being pregnant Breastfeeding Have no history of surgery in the last month Have no history of taking antifungal antibiotics in the past month J32.9 Chronic sinusitis, unspecified Treatment - Other Treatment - Other Intervention group: In this group, 40 patients, in addition to routine treatment, use amphotericin B solution for rinsing the nose twice a day for a month. Control group: In this group, in addition to routine treatment, 40 patients use normal saline solution for rinsing the nose twice a day for a month. Clinical status. Timepoint: At the end of 4 weeks. Method of measurement: Land Score. Recurrence of polyps. Timepoint: At the end of 4 weeks. Method of measurement: Based on endoscopic criteria of the nose. Mashhad University of Medical Sciences Approved 2019-08-13 Ethics committee of Mashhad University of Medical Science Central Building of Mashhad University of Medical Sciences (Ghorshi), Daneshgah 16, Daneshgah Street Mashhad Razavi Khorasan Iran (Islamic Republic of)