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IRCT20210920052535N1 IRCT 2022-06-26 Yazd University of Medical Sciences Comparison of the effectiveness of ozone and corticosteroid injections in the treatment of CTS Comparison of the effectiveness of local corticosteroid injection and local ozone injection in patients with carpal tunnel syndrome (CTS) 2021-05-22 anticipated 46 Complete https://irct.ir/trial/58846 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization was applied. In this method, patients were randomly divided into two groups using a table of random numbers by computer and online (using the site www.random.org/integres), Blinding description: Participants, the person who is completing the questionnaires and collecting the information, the person analyzing the information will be unaware of the group therapy and the type of injected substance. 3 Carpal Tunnel Syndrome. Intervention 1: First Intervention group: corticosteroid (40mg Triamcinolone) injection under the ultrasound-guide around the median nerve. Intervention 2: Second Intervention group: ozone (Ozone at a concentration of 10 micrograms per ml with 1 ml of 1% lidocaine) injection under the ultrasound-guide around the median nerve. Yes - There is a plan to make this available What will be shared: Information on the main outcome When: Start the access period 6 months after printing the results To whom: Only for researchers working in academic and scientific institutions Conditions: Confirming the responsible person Where to obtain: Dr Farnaz Hesam f.hesam@rocketmail.com How to obtain: Request by email Comments:
public Farnaz Hesam
Ebne Sina St, Shahid Ghandi Blvd, safaieh,Yazd
Yazd Iran (Islamic Republic of) ۸۹۱۵۸۸۷۸۵۷ +98 35 3822 4000 f.hesam@rocketmail.com Yazd University of Medical Sciences scientific Amidodin khatibi Aghda
Ebne Sina St, Shahid Ghandi Blvd, Safaieh,Yazd
Yazd Iran (Islamic Republic of) ۸۹۱۵۸۸۷۸۵۷ +98 35 3822 4000 dr.khatibi_2@yahoo.com Yazd University of Medical Sciences Iran (Islamic Republic of) Patients over 18 years with signs and symptoms of carpal tunnel syndrome confirmed by Electrodiagnostic study and have mild to moderate CTS according to it. 18 years no limit Both Age under 18 years Severe carpal tunnel syndrome Presence of underlying diseases such as diabetes, rheumatoid arthritis, thyroid disease and previous history of trauma Presence of thenar atrophy and peripheral nerve lesions of the upper extremity, polyneuropathy and radiculopathy Pregnancy, history of G6PD deficiency, thrombocytopenia, severe cardiovascular instability, people are receiving ACE-I History of injection or using a splint during the past 6 months or any previous surgery on the carpal tunnel G56.0 Carpal tunnel syndrome Treatment - Drugs Treatment - Drugs First Intervention group: corticosteroid (40mg Triamcinolone) injection under the ultrasound-guide around the median nerve. Second Intervention group: ozone (Ozone at a concentration of 10 micrograms per ml with 1 ml of 1% lidocaine) injection under the ultrasound-guide around the median nerve. The severity of symptoms and functional limitations. Timepoint: Zero and 8th week. Method of measurement: Boston questionnaire was applied. The severity of symptoms. Timepoint: Zero and 8th week. Method of measurement: Visual Analog Scale(VAS). Electrodiagnostic criteria. Timepoint: Zero and 8th week. Method of measurement: EMG-NCS device was applied. Sonographic criteria. Timepoint: Zero and 8th week. Method of measurement: Sonographic device was applied. Side effects. Timepoint: 8th week. Method of measurement: Questionnaire. Yazd University of Medical Sciences Approved 2021-05-19 Research Ethics Committees of School of Medicine- Shahid Sadoughi University of Medical Sciences Central building of Yazd University of Medical Sciences, Bahonar Sq, Yazd Yazd Yazd Iran (Islamic Republic of)