IRCT20210901052359N1 IRCT 2021-10-03 Iran University of Medical Sciences Cannabidiol in Restless Leg Syndrome Comparison of the effectiveness of Cannabidiol drop with Pramipexole in Restless Leg Syndrome severity index - randomized parallel clinical trial 2021-09-23 anticipated 40 Complete https://irct.ir/trial/58841 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: For the sampling plan, we will use the randomized quadruple block method to select ten random blocks according to the sample size. Patients will be respectively divided into two groups of A or B based on the randomized orders. Drugs of each group will be given to patients. Due to the different forms of drugs used (syrup and capsule), blinding can not be done; therefore, no concealment will be performed. 2-3 Restless Leg syndrome. Intervention 1: Intervention group: KMT(Khosro Medisa Teb) Group Cannabidiol C2 drops containing 5 mg per ml of the liposomal form of cannabidiol will be used. At the beginning of the intervention, one ml will be prescribed every night, and the titration will be done by increasing one cc per week for four weeks and then following up for another four weeks. During the titration phase, we will not increase the dose if the patient's symptoms resolved. Intervention 2: Control group: Pramipexole 0.18 tablets (containing 0.18 mg per tablet) will be used. In the first week, half a pill will be prescribed at night and the titration will be done by increasing half a pill per week for four weeks, and then following up for another four weeks. During the titration phase, we will not increase the dose if the patient's symptoms resolved. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information