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IRCT20210914052475N1 IRCT 2021-10-10 Research & technology assistance of Kharazmi University Augmenting cognitive behavioral therapy for obsessive-compulsive disorder with anti-disgust cognitive intervention Augmenting efficacy of cognitive behavioral therapy with anti-disgust cognitive intervention on disgust propensity/ sensitivity, emotion acceptance, and OCD severity in patients with obsessive-compulsive disorder 2021-10-17 anticipated 60 Complete https://irct.ir/trial/58754 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Education/Guidance, Randomization description: Randomization will be performed by a research assistant through the lottery method. First, the research assistant will give a code to each participant who met the eligibility criteria. The mentioned codes will be written on paper. Then, he will be poured all papers into an opaque container and intermittently allocated each participant to each group, Blinding description: The process of evaluation, randomization, and treatment for all participants will be conducted in two separate centers. In the first center, each participant will be evaluated by a research assistant who is blind to the study's objectives. He will assign each participant to one of two groups, as described in the randomization procedure. Then, each participant will refer to the second center to start the interventions. The second center is located at a one-kilometer distance from the first center. Therapists, researchers, evaluators, and data analysts will also present at the second center and will be utterly blind to the study objectives and which participant belonged to which group. N/A Obsessive_compulsive disorder. Intervention 1: Intervention group: cognitive-behavioral therapy plus anti-disgust cognitive intervention, 15 weekly sessions, time of each session: 90 minutes, case conceptualization, disgust-related cognitive psychoeducation & intervention, exposure and response prevention, relapse prevention. Intervention 2: Control group: cognitive-behavioral therapy, 15 weekly sessions, time of each session: 90 minutes, case conceptualization, exposure and response prevention, relapse prevention. No - There is not a plan to make this available Justification or reason for not sharing IPD is Privacy of personal information
public Dr Behzad Salmani
Iman 12 alley, Shahid Beheshti square, enghelab town, Meshkat
Kashan Iran (Islamic Republic of) 87391-14384 +98 31 5568 3234 b.salmani1365@gmail.com Kharazmi University scientific Dr Behzad Salmani
Iman 12 alley, Shahid beheshti square, enghelab town, Meshkat
Kashan Iran (Islamic Republic of) 87391-14384 +98 31 5568 3234 b.salmani1365@gmail.com Kharazmi University Iran (Islamic Republic of) Being at least 18 years old in the beginning of the study. Having an education grade equal to 12 or more. Diagnose with contamination-based obsessive-compulsive disorder as a primary diagnosis. Having a stable dose of medication from 3 months before the beginning of the study. Completing informed constant form. 19 years 40 years Both Diagnose with other comorbid psychiatric disorders or conditions except for major depressive disorder. Having a history of traumatic head injury or epilepsy. F42 Obsessive-compulsive disorder Behavior Behavior Intervention group: cognitive-behavioral therapy plus anti-disgust cognitive intervention, 15 weekly sessions, time of each session: 90 minutes, case conceptualization, disgust-related cognitive psychoeducation & intervention, exposure and response prevention, relapse prevention. Control group: cognitive-behavioral therapy, 15 weekly sessions, time of each session: 90 minutes, case conceptualization, exposure and response prevention, relapse prevention. Disgust propensity/ sensitivity. Timepoint: Pre-treatment, before exposure and response prevention sessions, post-treatment, three-month follow-up. Method of measurement: Disgust Propensity/ Sensitivity Scale (DPSS). Obsessive-compulsive disorder severity. Timepoint: Pre-treatment, before exposure and response prevention sessions, post-treatment, three-month follow-up. Method of measurement: Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Emotion acceptance. Timepoint: Pre-treatment, before exposure and response prevention sessions, post-treatment, three-month follow-up. Method of measurement: Non-judging & non-reactivity sub-scales of Five Facets Mindfulness Questionnaire. Acceptance rate of exposure and response prevention. Timepoint: Before exposure and response prevention sessions. Method of measurement: Percent of acceptance of exposure and response prevention. Research & technology assistance of Kharazmi University Approved 2021-09-14 Ethic committee of Kharazmi University Somayyeh building, Kharazmi University, South Moffateh st, Tehran Tehran Tehran Iran (Islamic Republic of)