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IRCT20200105046009N5 IRCT 2021-09-29 Babol University of Medical Sciences The effect of rhubarb (Rheum ribes L.) syrup in Children with acute diarrhea The effect of rhubarb (Rheum ribes L.) syrup in Children 1to 6 years with acute diarrhea 2021-10-01 anticipated 96 Complete https://irct.ir/trial/58665 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Based on the random number table, children are divided into two groups: A, rhubarb syrup + standard treatment, and B, control group, which is standard treatment+ placebo syrup. Randomization will be performed using size 4 permutation blocks. In this method, an equal number of drugs (A) and placebo (B) will be placed in each block in random order. This will be done by a statistician, Blinding description: In order to blind the drug and placebo, it will be uniform in color, color and smell and will be prepared in exactly the same packaging and jars. 3 Acute diarrhea. Intervention 1: Intervention group: Rhubarb syrup is prepared on the basis of USP 34 (USP simple syrup). USP simple syrup is based on water and sugar 66.7%. The syrup prepared is packaged in 120 ml amber jars with a label. The herbal medicine used in this design is a syrup made from the aqueous extract of R. ribes fruit. Preparation of R. ribes in the laboratory of medicines Herbal is performed by Shahid Beheshti School of Pharmacy in Tehran. The standard for total flavonoid content is 0.356 MG / ML in syrup. The total flavonoid on Rutin is also 7.13. The desired dose is 2.5 ml for children under 15 kg or 5 ml for children over 15 kg every 6 hours for 5 days. Intervention 2: Control group: placebo is made using a simple formula based on the USP standard of Pharmacoy Syrup, which includes a standard color, flavoring and appearance similar to rhubarb syrup. Finally, both products are placed in the same bottle and in the same packaging. will be provided. Yes - There is a plan to make this available What will be shared: Decide after the end of the study When: At the end of the study To whom: Academic researchers Conditions: Decide after the end of the study Where to obtain: email: seyyedali1357@gmail.com How to obtain: Ask via email: seyyedali1357@gmail.com Comments:

public Seyyed Ali Mozaffarpur

Ganjafruz st.

Babol Iran (Islamic Republic of) 4717647745 +98 11 3219 4728 seyyedali1357@gmail.com Babol University of Medical Sciences scientific Seyyed Ali Mozaffarpur

Ganjafruz ST.

Babol Iran (Islamic Republic of) 4717647745 +98 11 3219 4728 seyyedali1357@gmail.com Babol University of Medical Sciences Iran (Islamic Republic of) Children 1 to 6 years Acute diarrhea (loose stools for more than 3 times a day) in the last 72 hours Stool white blood cell count less than 5 / HPF in stool with or without mucus or blood Dehydration mild to moderate 1 year 6 years Both More than three days have passed since the onset of diarrhea Children treated with antibiotics or antidiarrheal drugs in the last 3 days History of pneumonia, sepsis, meningitis, or toxic colitis during diarrhea Entamoeba histolytica cyst, Giardia lamblia trophozoite in stool exam Dysentery (infectious or non-infectious ) Dry milk consumption Severe malnutrition (weight less than 60% or weight/height less than 70%) History of known chronic diseases Any type of food allergy Use of probiotics Immunodeficiency Other infections including urinary tract infections A08 Viral and other specified intestinal infections Treatment - Drugs Placebo Intervention group: Rhubarb syrup is prepared on the basis of USP 34 (USP simple syrup). USP simple syrup is based on water and sugar 66.7%. The syrup prepared is packaged in 120 ml amber jars with a label. The herbal medicine used in this design is a syrup made from the aqueous extract of R. ribes fruit. Preparation of R. ribes in the laboratory of medicines Herbal is performed by Shahid Beheshti School of Pharmacy in Tehran. The standard for total flavonoid content is 0.356 MG / ML in syrup. The total flavonoid on Rutin is also 7.13. The desired dose is 2.5 ml for children under 15 kg or 5 ml for children over 15 kg every 6 hours for 5 days. Control group: placebo is made using a simple formula based on the USP standard of Pharmacoy Syrup, which includes a standard color, flavoring and appearance similar to rhubarb syrup. Finally, both products are placed in the same bottle and in the same packaging. will be provided. Time to recovery. Timepoint: Counting the days of diarrhea up to the normal defecation. Method of measurement: Recovery time from acute diarrhea is defined as the time interval between admission and cessation of diarrhea or the first normal bowel movements, which in the Bristol stool diagram is equivalent to a score below 5. Duration of hospitalization. Timepoint: Counting the day of hospitalization (the days from hospitalization up to the discharge). Method of measurement: Counting the hospitalization days. Babol University of Medical Sciences Approved 2021-08-31 Ethics Committee of Babol University of Medical Sciences Ganjafrooz Street, Babol, Mazandaran, Iran Babol Mazandaran Iran (Islamic Republic of)