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IRCT20180619040147N8 IRCT 2021-10-19 Iranian academic center for education culture and research In Vitro Maturation of oocyte ّFeasibility evaluation of secretome obtained from menstrual blood derived stem cells accompanied with melatonin and follicular fluid in oocyte maturation of patients with polycystic ovary syndrome (PCOS). 2021-10-12 anticipated 90 Complete https://irct.ir/trial/58653 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: In this study for the first time, secretome obtained from menstrual blood derived stem cells accompanied with melatonin and follicular fluid of non poly cystic ovary syndrome patients in oocyte maturation will be evaluated. N/A Condition 1: In Vitro Maturation of oocyte. Condition 2: Polycystic ovarian syndrome. Intervention group: Immature oocytes. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Hilda Rastegari
Shariati St.
Tehran Iran (Islamic Republic of) 1941913114 22644755 rastegari_h@yahoo.com Iranian academic center for education culture and research scientific Somaieh Kazemnejad
Avicenna Research Institute, Shahid Beheshti University, Evin, Chamran Highway
Tehran Iran (Islamic Republic of) 1983969412 22432020 s.kazemnejad@ari.ir Iranian academic center for education culture and research Iran (Islamic Republic of) Polycystic ovary syndrome patients No background disease At least 4 immature oocyte Anti Mullerian hormone (AMH) higher than 1.3 No male factor 20 years 40 years Female Unable to give informed consent Background disease Immature oocyte lower than 4 Infectious disease human immunodeficiency virus (HIV), hepatitis C virus (HCV) and Hepatitis B. E28.2 Polycystic ovarian syndrome Treatment - Other Intervention group: Immature oocytes Oocyte maturation. Timepoint: 24 hours. Method of measurement: Detecting polar body under stereoscope. Embryo development after ICSI (Intra Cytoplasmic Sperm Injection). Timepoint: 24 and 48 hours after ICSI. Method of measurement: 2PN and cell division assessment under stereoscope. Embryo quality. Timepoint: 48 and 72 hours after ICSI. Method of measurement: Embryo assessment under stereoscope. Gene expression. Timepoint: 24 hours after treatment. Method of measurement: PCR (Polymerase Chain Reaction). Grant given from Ministry of Science to Top researcher in 2020 Approved 2021-08-24 Ethics Committee in research of Avicenna Research Institute Avicenna Research Institute, Shahid Beheshti University, Shahid Chamran Highway, Tehran, Iran Tehran Tehran Iran (Islamic Republic of)