IRCT20150721023282N21 IRCT 2021-11-07 Esfahan University of Medical Sciences Evaluation of the effectiveness of Berberis integerrima and Thyme essential oil in the treatment of acne Evaluation of the effectiveness of the combination of Berberis integerrima root extract and Thyme essential oil in the treatment of acne vulgaris Compared to clindamycin 2021-12-21 anticipated 40 Complete https://irct.ir/trial/58415 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: All the arrangements of the two groups will be drawn in pairs in quadruple blocks and each block will be numbered from 1 to the end. Using a table of random numbers, the blocks are selected in order and based on the arrangement of that block, patients will be divided into one of two groups according to the order of admission. 3 Acne vulgaris. Intervention 1: Intervention group: 5% Berberis integerrima extract and 1% thyme essential oil in 70% ethanol topical solution, made by Isfahan University of Medical Science, School of Pharmacy, for 28 days. Intervention 2: Control group: clindamycin 1% in 70% ethanol topical solution, made by Isfahan University of Medical Science, School of Pharmacy, for 28 days. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no necessity.