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IRCT201012205426N1 IRCT 2011-07-11 Vice chancellor for research, Kerman University of Medical Sciences Comparison of the effects of intra venous and epidural fentanyl on pain reliefو hemodynamic stability, airway resistance, pulmonary static compliance and arterial blood gas in patients with abdominal and thoracic trauma in ICU. Comparison of the effects of intra venous and epidural fentanyl on pain relief, hemodynamic stability, airway resistance, pulmonary static compliance and arterial blood gas in patients with abdominal and thoracic trauma in ICU. 2010-08-23 anticipated 60 Complete https://irct.ir/trial/5823 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Crossover, Purpose: Supportive. N/A Condition 1: chest trauma. Condition 2: Abdomen trauma. Intervention 1: Insertion of epidural catheter in the level of L1-T11 for administration of fentanyl (1 mic/kg/hour) for pain relief. Intervention 2: administration of fentanyl from intravenous line (2mic/kg/hour) for pain relif.
public Mehdi Ahmadinejad
ICU ward, Shahid Bahonar hospital
Kerman Iran (Islamic Republic of) +98 34 1223 5011 mehdia50@gmail.com Kerman University of Medical Sciences scientific Mehdi Ahmadinejad
ICU ward, Shahid Bahonar hospital
Kerman Iran (Islamic Republic of) +98 34 1223 5011 m.ahmadinejad@kmu.ac.ir; mehdia50@ gmail.com Kerman University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Patients with 16-80 year old age who are admitted in ICU due to chest or abdominal trauma and are under mechanical ventilation Exclusion criteria: Age under16 and above 80 yeasr old; BMI>30; Instability of spine; renal or hepatic insufficiency, ischemic heart disease,hypertension, diabetes mellitus; massive transfusion; shock and acute respiratory distress syndrome 16 years 80 years Both S21.7,S22. S31.1,S31. Multiple open wounds of thoracic wall ,Fracture of sternum,Multiple fractures of ribs ,Flail chest Open wound of abdominal wall ,Multiple open wounds of abdomen, lower back and pelvis,Other multiple injuries of abdomen, lower back and pelvis Treatment - Surgery Treatment - Drugs Insertion of epidural catheter in the level of L1-T11 for administration of fentanyl (1 mic/kg/hour) for pain relief administration of fentanyl from intravenous line (2mic/kg/hour) for pain relif Heart rate-. Timepoint: at 0-2-6-24-50-54-72 hours after admission of patents in icu. Method of measurement: Heart rate with ECG monitoring-. ABG. Timepoint: at 0-2-6-24-50-54-72 hours after admission of patents in icu. Method of measurement: ABG analyzer. Level of consciosness. Timepoint: t 0-2-6-24-50-54-72 hours after admission of patents in icu. Method of measurement: by GCS score. Static compliance-. Timepoint: at 0-2-6-24-50-54-72 hours after admission of patents in icu. Method of measurement: static compliance from patient data of ventilator. Airway resistance. Timepoint: at 0-2-6-24-50-54-72 hours after admission of patents in icu. Method of measurement: airway resistance from patient data of ventilator. Pain score-. Timepoint: at 0-2-6-24-50-54-72 hours after admission of patents in icu. Method of measurement: pain score with visual analog score. Blood pressure. Timepoint: at 0-2-6-24-50-54-72 hours after admission of patents in icu. Method of measurement: By non invasive BP monitoring of ICU. Decrease level of GCS. Timepoint: GCS is evaluated every 2 houre. Method of measurement: consciousness level with GCS-. Respiratory depression. Timepoint: respratory rate is monitored continiously in ICU. Method of measurement: respiratory rate by icu monitoring devices. Hypotension. Timepoint: BP is monitored every 1 hour-. Method of measurement: blood pressure with NIBP monitoring. Heart rate. Timepoint: heart rate is monitored continiously in ICU. Method of measurement: Heart rate with ECG monitoring-. Vice chancellor for research, Kerman University of Medical Sciences Approved 2010-08-20 Ethic committee, Kerman University of Medical Sciences Vice chancellor for research, Kerman University of Medical Sciences, Jahad street Kerman Iran (Islamic Republic of)