IRCT20180914041035N2 IRCT 2021-09-19 Tehran University of Medical Sciences Acupuncture effect in MS Associated Fatigue Comparison of the Effectiveness of Acupuncture Treatment with Routine Treatment on Fatigue among Patients with Multiple Sclerosis 2021-09-23 anticipated 60 Complete https://irct.ir/trial/58164 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: Patients will be randomized equally to intervention and control groups by simple individualized randomization method. For allocation of the participants, an Excel generated list of random numbers will be used. The allocation sequence will be concealed in sealed, opaque envelopes. After the initial evaluation and obtaining the written consent of enrolled participants, the corresponding envelopes will be opened, and the treatment allocation will be revealed. N/A Multiple Sclerosis. Intervention 1: Intervention group: The acupuncture group will receive acupuncture treatment through 10 sessions, 2-3 times per week (totally 4 weeks). All patients will also receive routine treatment with Interferon β-1a and Amantadine. According to textbooks and literature review, major selected acupoints for fatigue include Taixi (KI 3), Taichong (LR 3), Sanyinjiao (SP 6), Xuehai (SP 10), Zusanli (ST 36), Yanglingquan (GB 34), Guanyuan (CV 4), Qihai (CV 6), and Hegu (LI 4). Sterile stainless steel acupuncture needles (0.25mm × 40mm, Zhongyan Taihe medical instrument, Beijing, China) were inserted perpendicularly at a depth of 10-15 mm into the acupoints and will be retained for 20 minutes. Intervention 2: Control group: Control group will receive routine treatment with Interferon β-1a and Amantadine. IFN-β-1a (Avonex), 30 μg, is administered by intramuscular injection once every week. Amantadine 100mg will be used orally once a day. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more Information