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IRCT20210807052101N1 IRCT 2021-10-04 Rafsanjan University of Medical Sciences Effects of naproxen, diclofenac and piroxicam on Mandibular joint pain Comparison of the effects of Naproxen, Diclofenac and Piroxicam on TMD 2015-08-23 anticipated 104 Complete https://irct.ir/trial/58064 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: 104 patients randomly divided to 4 groups using random number table. A set of numbers without a specific pattern or order were generated in a completely random manner and became a table. In order to use the table of random numbers, the researcher first determined the table to read the numbers from above. Numbers 26-01 for prescription of naproxen, 27-52 for diclofenac, 78-53 for piroxicam and 104-79 for Placebo were also considered. The researcher then touched one of the numbers and moved in one of the predetermined directions, recording the numbers and assigning them to different groups, Blinding description: Three groups were blind: 1. Patients about their drugs 2. A dentist who examined the patients in periodic meetings (care provider) 3. Data analyser. 3 Temporo Mandibular Disorders. Intervention 1: The first Intervention group take Naproxen tablet 500 mg (Chemidarou, Tehran, Iran) twice a day for 10. Intervention 2: The second Intervention group: Diclofenac tablet 50 mg (Shahredaru, Tehran, Iran) twice a day for 10. Intervention 3: The third Intervention group: Piroxicam capsule 10 mg (Zahravi, Tehran, Iran) twice a day for 10 days. Intervention 4: Control group: Placebo twice a day for 10 days in the form of capsules similar to piroxicam and starch content. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Ali Peimani
Rafsanjan University of Medical Sciences, West Mofatteh blvd.
Rafsanjan Iran (Islamic Republic of) 7717933777 +98 34 3428 0038 alipeimani2001@yahoo.com Rafsanjan University of Medical Sciences scientific Ali Peimani
Rafsanjan University of Medical Sciences, West Mofatteh blvd.
Rafsanjan Iran (Islamic Republic of) 7717933777 +98 34 3428 0038 alipeimani2001@yahoo.com Rafsanjan University of Medical Sciences Iran (Islamic Republic of) Pain in masticatory muscles Limitation in mouth opening Clicking sound TMJ touch sensivity No systemic disease No previous supportive treatments 20 years 45 years Both Existence of systemic disease Receive previous supportive treatments M26.6 Temporomandibular joint disorders Treatment - Drugs Treatment - Drugs Treatment - Drugs Placebo The first Intervention group take Naproxen tablet 500 mg (Chemidarou, Tehran, Iran) twice a day for 10. The second Intervention group: Diclofenac tablet 50 mg (Shahredaru, Tehran, Iran) twice a day for 10. The third Intervention group: Piroxicam capsule 10 mg (Zahravi, Tehran, Iran) twice a day for 10 days. Control group: Placebo twice a day for 10 days in the form of capsules similar to piroxicam and starch content. Pain. Timepoint: Time table for evaluation patients includes; the first assessment before starting treatment, the second assessment one week after starting treatment, the third session three weeks after therapy, the fourth evaluation five weeks after treatment and the fifth session six weeks after therapy. Method of measurement: The amount of pain was measured with VAS index (visual analog scale). The amount of clicking. Timepoint: Time table for evaluation patients includes; the first assessment before starting treatment, the second assessment one week after starting treatment, the third session three weeks after therapy, the fourth evaluation five weeks after treatment and the fifth session six weeks after therapy. Method of measurement: The amount of clicking sound was measured with stethoscope. The amount of tenderness. Timepoint: Time table for evaluation patients includes; the first assessment before starting treatment, the second assessment one week after starting treatment, the third session three weeks after therapy, the fourth evaluation five weeks after treatment and the fifth session six weeks after therapy. Method of measurement: The degree of sensitivity to touch were done by touching the masticatory muscles and the joint area. The amount of opening mouth. Timepoint: Time table for evaluation patients includes; the first assessment before starting treatment, the second assessment one week after starting treatment, the third session three weeks after therapy, the fourth evaluation five weeks after treatment and the fifth session six weeks after therapy. Method of measurement: The amount of mouth opening was measured with a cloth ruler (the distance between the upper and lower incisors at the maximum amount of mouth opening). Rafsanjan University of Medical Sciences Approved 2015-05-22 Rafsanjan University of Medical Sciences Shahid mofatteh AVE Rafsanjan Kerman Iran (Islamic Republic of)