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IRCT201012195397N1 IRCT 2011-01-03 Vive-chancellor for research,Tehran University of Medical Sciences Effect of Aspirin on Estradiol level in Post menopausal women Effect of Aspirin on Estradiol level in Post menopausal women 2010-09-01 anticipated 40 Complete https://irct.ir/trial/5806 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A sexual hormone. Intervention 1: 100 milligram Aspirin daily for 6 weeks. Intervention 2: One Placebo capsule daily for 6 weeks.
public Mania Radfar
Tehran University of Medical Sciences, faculty of pharmacy, 16 Azar avenue
Tehran Iran (Islamic Republic of) +98 21 6695 4709 radfarma@tums.ac.ir; mania1352@yahoo.com Tehran University Of Medical Sciences scientific Mania Radfar
Tehran University of Medical Sciences, Faculty of pharmacy, 16 Azar avenue
Tehran Iran (Islamic Republic of) +98 21 6695 4709 radfarma@tums.ac.ir; mania1352@yahoo.com Tehran University Of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: age 45-80 years, not using NSAID drugs during past 3 months, not having menstruation cycle during the past 12 months, bilateral oophorectomy, hysterectomy without the bilateral oophorectomy with age more than 56 for smokers and age more than 54 years old for non-smokers, not using sexual hormones during the past 3 months Exclusion criteria:Taking NSAIDS or another inflammatory drugs, Inflammatory diseases, consuming of drugs that can alter the estradiol level for instance: inhibitor's aromotase enzyme, women who are candidate for surgery during the following 2-3 months, not willing to participate 45 years 85 years Female Treatment - Drugs Placebo 100 milligram Aspirin daily for 6 weeks One Placebo capsule daily for 6 weeks Estradiol. Timepoint: 6 weeks. Method of measurement: ELISA. SHBG (sex Hormone Binding Glubolin). Timepoint: 6 weeks. Method of measurement: ELISA. Testestrone. Timepoint: 6 weeks. Method of measurement: ELISA. Vive-chancellor for research,Tehran University of Medical Sciences Approved 2010-10-03 Vice-chancellor for research, Tehran University of Medical Sciences Central organization of Tehran University of Medical Sciences, Ghods avenue, Keshavarz Blvd, Tehran Tehran Iran (Islamic Republic of)