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IRCT20190905044704N1 IRCT 2021-08-19 Mashhad University of Medical Sciences Effect of heparin in the prevention of central vein catheter The effect of intermediate dose of heparin solution in the prevention of central vein catheter occlusion on ICU admitted patients 2021-09-06 anticipated 150 Complete https://irct.ir/trial/57908 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Simple randomization in this way that Heparin and normal saline solution divided in number "one" and number "two" solution that nurse and patient do not know that and use this solution for patients with randomization, Blinding description: Heparin and normal salin solution divided in number one and number two solution that nurse and patient do not know that. 3 Central vein catheters occlution. Intervention 1: Intervention group: The active and inactive lines in the intervention group will be washed every 8 hours with 10 ml of saline solution and then locked with 1.5 ml of heparin solution at a concentration of 100 units per ml untill 14 days. Intervention 2: Control group: In the control group, only saline washing will be performed untill 14 days. Yes - There is a plan to make this available What will be shared: All data is shared after unidentifiable people When: 6 months after publishing To whom: Researchers working in academic institutions Conditions: Use data to compare with other similar interventions Where to obtain: bagheria@mums.ac.ir How to obtain: email request Comments:
public Asieh Yahyaie
ICU C, second floor, Edalatian Department, Emam Reza Hospital, Mashhad
Mashhad Iran (Islamic Republic of) 9137913316 +98 51 3802 3763 yahyaeia961@mums.ac.ir Mashhad University of Medical Sciences scientific Asieh Yahyaie
ICU C, second floor, Edalatian Department, Emam Reza Hospital, Mashhad
Mashhad Iran (Islamic Republic of) 9137913316 +98 51 3802 3763 yahyaeia961@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) All ICU admitted patients who had 3 functional lumen catheter that insert less than 12 hours 18 years no limit Both Dialysis and phresis and pulmonary artery catheters and insertable ports Age less than 18 y/o Pregnancy Heparin sensivity and HIT Coagolation system disorder and thrombocytopenia Therapeutic dose of anticoagolant Packed cell or any blood products transfusion TPN If the active lines needed more than 3 time hepparizination were excluded T85 Complications of other internal prosthetic devices, implants and grafts Treatment - Drugs Treatment - Drugs Intervention group: The active and inactive lines in the intervention group will be washed every 8 hours with 10 ml of saline solution and then locked with 1.5 ml of heparin solution at a concentration of 100 units per ml untill 14 days. Control group: In the control group, only saline washing will be performed untill 14 days. Central vein catheter occlution. Timepoint: Central vein catheters was checked every 8 hours untill 14 days. Method of measurement: Aspiration and infusion. Mashhad University of Medical Sciences Approved 2019-10-25 Ethics Committee of Mashhad University of Medical Science Office off Research and Technology, Ghoreishi Building, Near Hoveize Cinema, Daneshgah Street Mashhad Razavi Khorasan Iran (Islamic Republic of)