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IRCT20210729052010N1 IRCT 2021-12-24 Esfahan University of Medical Sciences Comparison of Efficacy Permethrin topical Cream in Combination with Doxycycline Tablet with Ivermectin topical Cream in Combination with Doxycycline Tablet in Treatment of cutaneus disease Rosacea Patients Comparison of Efficacy Permethrin 5% Cream with Ivermectin 1% Cream in Combination with Oral Doxycycline in Treatment of Papulopustular Rosacea Patients 2022-01-21 anticipated 40 Complete https://irct.ir/trial/57881 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: For Randomization is used from table of random numbers.in this study there is two treatment groups(treatment by permetrin 5% cream=A and treatment by Ivermectin 1% cream=B).every odd number an assignment to A and every even number an assignment to B.we close our eyes and put a finger anywhere on the table and write the column and row number that will our starting point and also write the direction we wil move in the table from starting point horizentally to the left.then we will write assignmented treatment by intended randomized number and when the first patient will enroll,the first assignmented treatment will be done and second treatment for second patient and so on.when the number of group A or B patients completed,we forced assign the rest of number of patients to notcompletedgroup.although it is possible to create equal vigesimal groups that in this case does not need to do above way. in this way ,treatment assignment for next patient is not predictable.In this study the patients have equal chance for selection in one of two intervention groups.In this study we don’t use from stratified randomization for example patients of case study don’t grouping based on sex and agenand other factors, Blinding description: Drugs is delivered by pharmacist in similar tubes but coded tube without information of the treating physician and patients from the type of drugs. 3 Rosacea papulopustular disease. Intervention 1: First Intervention group:use of permethrin 5% topical cream produced by Gilan daroo company for 12 weeks on cutaneus lesions for 20 papulopustular rosacea patients and photography from their cutaneus lesions in 0 and 6 and 12 weeks after treatment and compare photos together. Intervention 2: second Intervention group:use of Ivermectin 1% topical cream produced by Gilan daroo company for 12 weeks on cutaneus lesions for 20 papulopustular rosacea patients and photography from their cutaneus lesions in 0 and 6 and 12 weeks after treatment and compare photos together. Yes - There is a plan to make this available What will be shared: Comparison of Efficacy Between Permethrin 5% Cream and Ivermectin 1% Cream in Combination with Oral Doxycycline in Treatment of Papulopustular Rosacea Patients When: It will be published as soon as the research project is completed To whom: Every body Conditions: In order to inform and under any circumstances Where to obtain: To the site How to obtain: It have not special process Comments:
public Nazila Poostiyan
Soffe Ave., Alzahra Hospital
Isfahan Iran (Islamic Republic of) 8174675731 +98 31 3620 2020 Alzahra@mui.ac.ir Esfahan University of Medical Sciences scientific Nazila Poostiyan
Soffe Ave., Alzahra Hospital
Isfahan Iran (Islamic Republic of) 8174675731 +98 31 3620 2020 Alzahra@mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Diagnosis of typical papulopustular rosacea according two dermatologists and performance biopsy if rosacea is suspected No treatment with topical steroids or other topical treatment during 14 days before starting study No treatment with any systemic drugs by known effect on inflammation responses during 30 days before starting study No treatment with topical retinoids during 30 days ago or systemic retinoids during 180 days before starting study No treatment by physical modality that effect on rosacea lesions during 30 days before starting study Absence of other cutaneous diseases that interfere with assessment lesions related to rosacea Absence of comedon, cyst and scar that benefit to diagnosis of acne vulgaris Absence of pregnancy and breastfeeding 18 years no limit Female Less than 18 years Male gender Treatment - Drugs Treatment - Drugs First Intervention group:use of permethrin 5% topical cream produced by Gilan daroo company for 12 weeks on cutaneus lesions for 20 papulopustular rosacea patients and photography from their cutaneus lesions in 0 and 6 and 12 weeks after treatment and compare photos together second Intervention group:use of Ivermectin 1% topical cream produced by Gilan daroo company for 12 weeks on cutaneus lesions for 20 papulopustular rosacea patients and photography from their cutaneus lesions in 0 and 6 and 12 weeks after treatment and compare photos together Increase or decrease number and severity after use Ivermectin 1% cream or permetrin 5% cream. Timepoint: 0,6 and 12 weeks after starting treatment. Method of measurement: Photography from lesions and remission of lesions. Esfahan University of Medical Sciences Approved 2020-09-04 Ethics Committee of Isfahan University of Medical Sciences Soffe Ave., Alzahra Hospital Isfahan Isfehan Iran (Islamic Republic of)