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IRCT201012115364N1 IRCT 2011-03-07 Vice Chancellor for Research & Technology Affairs Effects of Dexamethasone on the prevention of elevation of C-reactive protein and pain following laparoscopic cholecystectomy Effects of Dexamethasone on the prevention of elevation of C-reactive protein and pain following laparoscopic cholecystectomy 2010-07-23 anticipated 68 Complete https://irct.ir/trial/5760 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. 2-3 Cholelithiasis. Intervention 1: 2cc intravenous normal saline. Intervention 2: 8 mg (2cc) intravenous dexametasone.
public Dr Khosrow Setaishy
No. 60, Naft st., Golestan cross
Kermanshah Iran (Islamic Republic of) +98 83 1427 6310 k.setaishy@gmail.com Kermanshah University of Medical Sciences scientific Dr Khosrow Setaishy
No. 60, Naft st., Golestan cross
Kermanshah Iran (Islamic Republic of) +98 83 1427 6310 k.setaishy@gmail.com Kermanshah University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: patients with diagnosis of cholelithiasis who are candidate for laparoscopic cholecystectomy. Exclusion criteria: pregnancy, age under 18 or over 80 years, body mass index over 30, presence of underlying disease, associated infection, history of previous abdominal surgery, diagnosis of empyema of gallbladder, usage of steroids and opioids during last week, and all situations which anesthetic drugs administration is contraindicated in, the selected cases will be enrolled after writing consent. 18 years 80 years Both K80.2 Calculus of gallbladder without cholecystitis Placebo Treatment - Drugs 2cc intravenous normal saline 8 mg (2cc) intravenous dexametasone Pain intensity. Timepoint: 6 hours, 12 hours and 24 hours after surgery. Method of measurement: visual analog scale (VAS). Serum Level of CRP. Timepoint: Before surgery and 6, 12 and 24 hours after surgery. Method of measurement: level of serum CRP with Elisa assay. Amount of analgesic required. Timepoint: If the patient expressed pain. Method of measurement: miligram. Vice Chancellor for Research & Technology Affairs Approved 2010-07-13 Kermanshah University of Medical Sciences Shahid Beheshti blvrd. Kermanshah Iran (Islamic Republic of)