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IRCT201212291323N5 IRCT 2013-02-11 Deputy of information and Research , Yasuj University of Medical Science sterile water and normal saline in PCNL comparison of efficacy and adverse effects of sterile water and normal saline for irrigation fluid in percutneous nephrolithotripsy(PCNL) 2011-06-01 anticipated 94 Complete https://irct.ir/trial/574 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Calculus of kidney with calculus of ureter. Intervention 1: Case group :use of sterile water as an irrigation fluid during PCNL operation. Intervention 2: control group :use of normal saline as an irrigation fluid during PCNL operation. J Mazand Univ Med Sci 2013; 23(106): (Persian). Comparison of the Efficacy and Adverse Effects of Sterile Water with<br /> Normal Saline in Percutaneous Nephrolithotomy (PCNL)<br /> Sadrollah Mehrabi1,<br /> Samira Nazari2,<br /> Hammidreza Ghafarian Shirazi3,<br /> Abolghasem Hadinia4,<br /> 1 Professor, Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran<br /> 2 General Practitioner, Students Research committee, Yasuj University of Medical Sciences, Yasuj, Iran<br /> 3 Assistant Professor, Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran<br /> 4 Lecturer, Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran<br /> (Received July 14, 2012; Accepted December 15, 2012)<br /> Abstract<br /> Background and purpose: The irrigation fluid that routinely used during percutaneous nephrolithotomy<br /> (PCNL) has systemic absorption. The aim of this study was comparing the efficacy and adverse effects of sterile<br /> water and normal saline as an irrigant fluid in PCNL.<br /> Materials and methods: Ninety four older than 18 years old patients with renal or upper ureteral stones<br /> that were candidate for PCNL randomly allocated in two groups. Patient with American Society of Anesthesiologists<br /> (ASA) score 3 and 4 and history of hemolysis excluded from study. From all patient, serum base laboratory and<br /> serum electrolyte was taken. Then, under spinal anesthesia PCNL was done with fluoroscope guidance in standard<br /> method with use of normal saline in first group. In second group, PCNL with fluoroscope guidance in standard<br /> method with use of sterile water was done, too. Preoperative, intraoperative and postoperative variables such as<br /> serum sodium, potassium and haptoglobin, cost and duration of surgery, pulmonary and cardiovascular<br /> complications compared between two groups. Data was collected and analyzed using chi-square and paired -t tests.<br /> Results: Demographic characteristics, operation time, serum electrolytes and volume of irrigation fluid were<br /> similar in two groups. Mean postoperative haptoglobin in group one and two were 1.15 ± 0.38 and 1.29 ± 0.53 mg/dl<br /> respectively (P = 0.263). Mean cost in group one and two were 117,234 and 25,400 Rial, respectively and there were<br /> no cardiovascular and pulmonary complications.<br /> Conclusion: Use of sterile water as an irrigation fluid in PCNL is inexpensive, safe and more available and<br /> have not more complications in compare with normal saline that can be used as an alternative fluid in PCNL<br /> operation.<br /> Keywords: Sterile water, normal saline, PCNL
public Dr Sadrollah Mehrabi
Montazeri street,Shaheed Beheshti Hospital,
Yasuj Iran (Islamic Republic of) 7591741417 +98 74 1222 1813 sadrollahm@yahoo.com and dr mehrabiyums.ac.ir Social Health Determinant of research center,Yasuj university of medical science scientific Dr Sadrollah Mehrabi
Block 22,no1,bahonar street,Dr Mehrabi
Yasuj Iran (Islamic Republic of) +98 74 1222 1813 sadrollahm@yahoo.com and dr.mehrabi@yums.ac.ir Social determinant of health research center,, Yasuj University of Medical Science Iran (Islamic Republic of) inclusion and exclusion criteria are includes (Inclusion criteria:Age>18 years old ,patients with renal or upper ureteral stone larger than 20 millimeter candidate for percutaneous nephrolithotripsy , Exclusion criteria: patients with urinary stone younger than 18 years old ,patients with azotemia.uncontrolled coagulopathy,active infection,history of hemolysis,any contraindication for general or spinal anesthesia,COPD,ASA score 3 and 4 ) 18 years no limit Both N20.2 Calculus of kidney with calculus of ureter Treatment - Surgery Treatment - Surgery Case group :use of sterile water as an irrigation fluid during PCNL operation control group :use of normal saline as an irrigation fluid during PCNL operation Cheke of serum electrolytes and hemolysis in percutaneous nephrolithotripsy. Timepoint: Before operation and 6 hour after operation. Method of measurement: checking Na,K,and serum haptoglubin before and 6 hour operation. Development of any cardiovascular or pulmonary complications. Timepoint: during operation to one week later. Method of measurement: report of patients and observation with examination lung and heart of of patients pulse oximetery during operation,and check of lower limb pulses. Deputy of information and Research , Yasuj University of Medical Science Approved 2011-03-01 Ethics committee of Yasuj University of Medical Sciences Motahari street,yasuj university of medical sciences Yasuj Iran (Islamic Republic of)