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IRCT20210515051306N1 IRCT 2021-07-07 Rafsanjan University of Medical Sciences anesthetic efficacy of 1.8 mL articaine, 1.8 mL and 3.6 mL of lidocaine for mental nerve block in irreversible pulpitis of the mandibular premolar MINB Comparative evaluation of anesthetic efficacy of 1.8 mL articaine, 1.8 mL and 3.6 mL of lidocaine for mental nerve block in mandibular premolar with irreversible pulpitis 2021-06-22 anticipated 165 Complete https://irct.ir/trial/57211 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomizzation individually 3 categories (1.8 lidocaine, 1.8 articaine and 3.6 lidocaine) were written on 165 pieces of paper and kept in sealed envelopes, Blinding description: The first practitioner who perform the local anesthetic injection will open the envelope, and based on the category each patient will receive either 2 cartridges of the anesthetic solution or a cartridge of the anesthetic solution followed by a mock injection. Another practitioner will perform the rest of the treatment including access cavity preparation and root canal instrumentation. Hence, the second practitioner and the patients won't be aware of the volume of anesthetic solution used. N/A irreversible pulpitis of the mandibular premolar. Intervention 1: 1st Intervention group: The mental nerve block involved adeposition of 1.8 mL 2% lidocaine with1:80,000 epinephrine (Xilonibsa, Inibsa, Barcelona, Spain) each patient received 2 cartridges of the anesthetic solution. the treatment including access cavity preparation and root canal instrumentation were performed 2-3 minutes after the injection. The patients were asked to rate their pain using a Heft-Parkervisual analog pain scale (VAS) before administration of the anesthetic solution and during the endodontic treatment. Intervention 2: 2nd Intervention group: The mental nerve block involved a deposition of 1.8 mL 4% articaine with1:100,000 epinephrine (Artinibsa, Inibsa, Barcelona, Spain) each patient received a cartridge of the anesthetic solution followed by a mock injection. The treatment including access cavity preparation and root canal instrumentation were performed 2-3 minutes after the injection. The patients were asked to rate their pain using a Heft-Parkervisual analog pain scale (VAS) before administration of the anesthetic solution and during the endodontic treatment. Intervention 3: 3rd Intervention group: The mental nerve block involved adeposition of 1.8 mL 2% lidocaine with1:80,000 epinephrine (Xilonibsa, Inibsa, Barcelona, Spain) each patient received a cartridge of the anesthetic solution followed by a mock injection. The treatment including access cavity preparation and root canal instrumentation were performed 2-3 minutes after the injection. The patients were asked to rate their pain using a Heft-Parkervisual analog pain scale (VAS) before administration of the anesthetic solution and during the endodontic treatment. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no more information
public Ramin Abazarpoor
Dental school, Khalij-e fars Blvd.
Rafsanjan Iran (Islamic Republic of) 7717931136 +98 34 3428 0031 ram_aba@yahoo.com Rafsanjan University of Medical Sciences scientific Ramin Abazarpoor
Khalij-e fars Blvd., Dentistry Faculty
Rafsanjan Iran (Islamic Republic of) 7717931136 +98 34 3424 2322 abazarpoor@rums.ac.ir Rafsanjan University of Medical Sciences Iran (Islamic Republic of) Healthy adult patients 18–60 years old Having a mandibular premolar tooth with symptomatic irreversible pulpitis Normal periapical radiographic appearance 18 years 60 years Both History of sensitivity to 4%articaine or epinephrine Systemic diseases Pregnancy or breastfeeding Any type of medication that could potentially interact with the anesthetic solution Spontaneous pain Periodontal disease or unable to get restoration Having pain killer late 12 hours K04.0 Pulpitis Treatment - Drugs Treatment - Drugs Treatment - Drugs 1st Intervention group: The mental nerve block involved adeposition of 1.8 mL 2% lidocaine with1:80,000 epinephrine (Xilonibsa, Inibsa, Barcelona, Spain) each patient received 2 cartridges of the anesthetic solution. the treatment including access cavity preparation and root canal instrumentation were performed 2-3 minutes after the injection. The patients were asked to rate their pain using a Heft-Parkervisual analog pain scale (VAS) before administration of the anesthetic solution and during the endodontic treatment. 2nd Intervention group: The mental nerve block involved a deposition of 1.8 mL 4% articaine with1:100,000 epinephrine (Artinibsa, Inibsa, Barcelona, Spain) each patient received a cartridge of the anesthetic solution followed by a mock injection. The treatment including access cavity preparation and root canal instrumentation were performed 2-3 minutes after the injection. The patients were asked to rate their pain using a Heft-Parkervisual analog pain scale (VAS) before administration of the anesthetic solution and during the endodontic treatment. 3rd Intervention group: The mental nerve block involved adeposition of 1.8 mL 2% lidocaine with1:80,000 epinephrine (Xilonibsa, Inibsa, Barcelona, Spain) each patient received a cartridge of the anesthetic solution followed by a mock injection. The treatment including access cavity preparation and root canal instrumentation were performed 2-3 minutes after the injection. The patients were asked to rate their pain using a Heft-Parkervisual analog pain scale (VAS) before administration of the anesthetic solution and during the endodontic treatment. Pain score during treatment on Visual Analogue Scale (VAS). Timepoint: before administration of the anesthetic solution and during the endodontic treatment. Method of measurement: Visual Analogue Scale (VAS). Rafsanjan University of Medical Sciences Approved 2021-06-22 Ethics committee of Rafsanjan University of Medical Sciences Imam Ali Blv. Rafsanjan Kerman Iran (Islamic Republic of)