]>
IRCT20100101002950N7 IRCT 2021-09-17 Rasht University of Medical Sciences Evaluation of the efficacy of oral curcumin on complex aphthous Evaluation of the efficacy of oral curcumin on recurrency and number of complex aphthous lesions in the patients referred to the Oral and maxillofacial medicine Department of Guilan Dental School in 2021-2022 2021-09-16 anticipated 15 Complete https://irct.ir/trial/57070 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. 2-3 Oral complex aphthous. Intervention group:Consumption of 2 oral sina Curcumin capsule 40 mg once a day for 1 month. Yes - There is a plan to make this available What will be shared: Data will shareable after making them unidentifiable When: Accessibility will starts from 6 month after publish To whom: Data will be available to researchers working in academic and scientific institutions. Conditions: They can use them with refrence Where to obtain: Dr.seyed javad kia djavadkia@yahoo.com How to obtain: After receiving the request, the documents will be delivered to the applicant within one month. Comments:
public Dr. Seyed Javad Kia
Guilan dental school, Fuman-Saravan Rd
Rasht Iran (Islamic Republic of) 41941-73774 009813336416 DJavadkia@gums.ac.ir Rasht University of Medical Sciences scientific Dr. Seyed Javad Kia
Guilan dental school, Fuman-Saravan Rd
Rasht Iran (Islamic Republic of) 41941-73774 +98 13 3348 6416 DJavadkia@gums.ac.ir Rasht University of Medical Sciences Iran (Islamic Republic of) Patients between the ages of 20 and 60 years Complex aphthous ulcers, which include: a number of painful aphthous lesions on the oral mucosa that appear intermittently and heal slowly; Created in less than 72 hours 20 years 60 years Both Patients taking topical medication to treat the aphthous in the last two weeks or taking systemic medication in the last one month Patients with systemic diseases such as intestinal and gastric diseases (Crohn's and ulcerative colitis), Behcet's disease, Reiter's syndrome and gallstones Patients with anxiety disorders Patients with bracets Pregnant and lactating women Patients with a history of alcohol and drug use Patients treated with immunosuppressants, chemotherapy, and immunomodulatory drugs over the past year History of allergies to plant compounds, including turmeric High liver enzymes Use of anticoagulants or antiplatelets (curcumin has an inhibitory effect on platelet aggregation) such as Warfarin, Aspirin, Clopidogrel, Epixaban, Rivaroxaban, Heparin and Enoxaparin History of gastric ulcer and duodenal ulcer Patients with inadequate literacy who do not understand the consent form K12.0 Recurrent oral aphthae Treatment - Drugs Intervention group:Consumption of 2 oral sina Curcumin capsule 40 mg once a day for 1 month The recurrence of ulcers. Timepoint: 2, 4 and 8weeks after consumption of the medicine. Method of measurement: With physical examination of patients and based on the time after taking the drug that the disease will occurs again. The number of aphthous lesion. Timepoint: At the beginning of treatment and 2 weeks, 4 weeks and 8 weeks after consumption of the medicine. Method of measurement: Count the number of lesions through examination. Functional complications. Timepoint: At the beginning of treatment and 2 weeks, 4 weeks and 8 weeks after consumption of the medicine. Method of measurement: Use of visual analoge scale (VAS) from 0-10. 0: The least discomfort and interference of the lesions with the patient speaking, chewing and brushing. 10: The highest amount of interference. Patient satisfaction with treatment. Timepoint: 2, 4 and 8weeks after consumption of the medicine. Method of measurement: Use of visual analoge scale. 0-7: Dissatisfaction 8-10: Satisfaction. The size of aphthous lesion. Timepoint: At the beginning of treatment and 2 weeks, 4 weeks and 8 weeks after consumption of the medicine. Method of measurement: Using a sterile vernier caliper. The severity of pain. Timepoint: At the beginning of treatment and 2 weeks, 4 weeks and 8 weeks after consumption of the medicine. Method of measurement: Use of visual analoge scale (VAS) from 0-10. 0:no pain - 10: severe pain. Rasht University of Medical Sciences Approved 2021-09-01 Ethics committee of Guilan University of Medical Science Assistance office of Research and Technology, Namjoo St. Shahid Siadati St., in front of 17 Shahrivar hospital, Rasht Guilan Iran (Islamic Republic of)