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IRCT20110109005570N11 IRCT 2021-07-22 Esfahan University of Medical Sciences Effect of Atorvastatin gel on clinical and histological parameters in socket preservation Determining the effects of using 1.2% Atorvastatin gel with absorbable membrane on clinical and histological parameters in socket preservation 2021-07-23 anticipated 15 Complete https://irct.ir/trial/57046 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In each patient, one dental socket is selected as the case and the other socket as the control. Randomization method for selecting the socket in each patient is done by the sealed envelope, Blinding description: The participant is not able to identify the type of treatment performed. The person performing the histological examination is not aware of the type of treatment. N/A socket preservation. Intervention 1: Intervention group: extraction of tooth and placing atorvastatin gel in socket and covering it with claprotect membranes made by Bottis company and then suturing on it. Intervention 2: Control group: extraction of tooth and covering socket by claprotect membranes made by Bottis company and then suturing on it. Yes - There is a plan to make this available What will be shared: All data can be shared after unidentifying individuals When: Start the access period after printing the results To whom: for all researcher Conditions: For a comparative study Where to obtain: Dr. Negin Hosseini, assistant professor of dental school, Shiraz University of Medical Sciences How to obtain: Request via email to the corresponded and will be send within 3 months after review Comments:
public Parichehr Behfarnia
Isfahan University of Medical Sciences, Hezar Jarib St.
Isfahan Iran (Islamic Republic of) 8174673761 +98 31 3792 5559 behfarnia@dnt.mui.ac.ir Esfahan University of Medical Sciences scientific seyedh Negin Hosseini
Dental School, Shiraz University of Medical Sciences, Ghasrodasht St,
Shiraz Iran (Islamic Republic of) 7195615878 +98 71 3626 3193 n.hosseini67@yahoo.com Shiraz University of Medical Sciences Iran (Islamic Republic of) Patient with healthy systemic condition Single-rooted or double-rooted teeth Presence of sound buccal and lingual plates after tooth extraction Presence of a minimum of 10 mm vertical bone height without invading the adjacent critical structures, 30 years 50 years Both Allergy to collagen membrane Severe untreated periodontitis Acute infection or pus at the extraction site K08.40 Partial loss of teeth, unspecified cause Treatment - Other Treatment - Other Intervention group: extraction of tooth and placing atorvastatin gel in socket and covering it with claprotect membranes made by Bottis company and then suturing on it Control group: extraction of tooth and covering socket by claprotect membranes made by Bottis company and then suturing on it Length of socket. Timepoint: Before the intervention and 2 months after the intervention. Method of measurement: Periodontal probe. Width of socket. Timepoint: Before the intervention and 2 months after the intervention. Method of measurement: Periodontal probe. Width of keratinized gingiva. Timepoint: Before the intervention and 2 months after the intervention. Method of measurement: Periodontal probe. Thickness of gingiva. Timepoint: Before the intervention and 2 months after the intervention. Method of measurement: Periodontal probe. Percent of ossification of alveolar socket. Timepoint: 2 months after the intervention. Method of measurement: Histological evaluation. Thickness of new trabecula. Timepoint: 2 months after the intervention. Method of measurement: Histological evaluation. Esfahan University of Medical Sciences Approved 2020-05-31 Ethics committee of Isfahan University of Medical Sciences Hezar Jarib- Isfahan University of Medical Sciences Esfahan Isfehan Iran (Islamic Republic of)