IRCT20200414047076N2 IRCT 2021-09-08 Esfahan University of Medical Sciences The assessment of the effect of plasmapheresis treatment for the management of sever COVID-19 patients Evaluation of the Effect of Plasmapheresis Treatment for the Management of Patients with Severe COVID19 2021-06-22 anticipated 70 Complete https://irct.ir/trial/57036 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomized allocation will be done by some one who is not among the study researchers. The codes of participants will be entered in SPSS software which will allocated randomly to intervention or control groups. N/A Covid-19,Plasmapheresis. Intervention 1: The intervention group: The COVID-19 patients who will receive Centrifugation plasmapheres which are replaced by FFP. The Plasmapheresis , Lab tests and clinical examinations will be done every other day for treatment decision making. The treatment with plasmapheresis will be 3-5 times. Intervention 2: Control group: Patients will receive routine treatments for Covid disease. Yes - There is a plan to make this available What will be shared: Collect information in the form of articles When: One year To whom: all Conditions: After publishing the article Where to obtain: executor of plan How to obtain: Send your request via email Comments: Due to the importance of treating patients with COVID 19, any guidance and questions will be answered by the facilitator