IRCT20161204031229N5 IRCT 2021-09-13 Iran University of Medical Sciences The effect of Coenzyme Q10 in depressed patients Comparing the effect of coenzyme Q10 and placebo on the severity of depressive symptoms in the treatment of patients with (major) depression 2021-09-01 anticipated 74 Complete https://irct.ir/trial/57035 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: Neither the participants or the experimenters know who is receiving a particular treatment and the patients are randomized into intervention group or placebo group by cards shuffling method, Randomization description: In this study, we will use the Restricted randomization method of block randomization. All blocks are the same size, and in this two-group experiment we will have blocks of size 6 (including 3 participants in the intervention and 3 participants in the control groups). Random allocation software is also used to randomize random sequence production software (Random allocation software). For concealment, we also use concealment allocation, Blinding description: All participants in the study, including participants, clinical caregivers, researchers, etc., are kept blind. Of course, before starting the study, informed consent is obtained from the participants. But because drugs and placebo are similar in shape and different in content, practically no one knows their true nature. 3 Depression. Intervention 1: Intervention group: 200 mg coenzyme Q10 twice daily plus standard treatment of depression for 8 weeks. Intervention 2: Control group: Placebo plus standard treatment for depression for 8 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information