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IRCT20210513051275N1 IRCT 2021-07-06 Islamic Azad University The Evaluation of effectiveness of heparin nebulizer in reduction of respiratory distress in patients with COVID-19 The Evaluation of effectiveness of heparin nebulizer in reduction of respiratory distress in patients with COVID-19 2021-08-06 anticipated 60 Complete https://irct.ir/trial/56935 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: 60 patients selected by simple random sampling and Using a table of random numbers, they will be divided into two groups of 30 intervention and placebo. Then, 60 questionnaires were prepared in advance, on 30 of which were group A and It is written on the other 30 numbers of group B. It is given to the patient and the patient is asked to choose one of them blindly. If he chooses A, he will receive a heparin nebulizer and If B is selected, the same amount of normal saline will be nebulized for it, Blinding description: En Only patients are unaware of how to group and the amount and type of medication used It is necessary to mention in this research the drugs used and Their levels in both experimental groups are completely routine and tested. 2-3 COVID-19. Intervention 1: Intervention group: They will be treated with a heparin nebulizer at a dose of 5,000 units every 8 hours. Intervention 2: Intervention group: They will be treated with normal saline (placebo) at a dose of 5,000 units every 8 hours. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public ِDr.Maryam Tavakoli
Shohada kargar hospital, Modares blvd, Yazd
Yazd Iran (Islamic Republic of) 8915813135 +98 35 3825 4040 shohadakargar.hos@tamin.ir Islamic Azad University scientific ِDr.Maryam Tavakoli
Shohada kargar hospital, Modares blvd, Yazd
Yazd Iran (Islamic Republic of) 8915813135 +98 35 3825 4040 shohadakargar.hos@tamin.ir Islamic Azad University Iran (Islamic Republic of) Iran (Islamic Republic of) All patients with COVID-19 treated in Yazd In the Summer of 2021, which was proven by radiographic involvement in radiography andThey have respiratory distress and O2 SAT below 90%. no limit no limit Both Patients treated with anticoagulants Patients with a variety of coagulation disorders Patients who have impaired coagulation tests at initial evaluation. Patients with proven cardiovascular disease Patients taking medications that interfere with the medications we use. Patients with severe COVID-19 who require ICU admission and mechanical ventilation prior to intervention. Patients who do not have clear lung involvement on radiography and respiratory distress. U07.1 COVID-19, virus identified Treatment - Drugs Placebo Intervention group: They will be treated with a heparin nebulizer at a dose of 5,000 units every 8 hours Intervention group: They will be treated with normal saline (placebo) at a dose of 5,000 units every 8 hours Number of breaths. Timepoint: Before the intervention and three days after the start of the intervention. Method of measurement: Cardiac device for monitoring and recording information in a questionnaire. Percentage of arterial blood oxygen saturation (SpO2). Timepoint: Before the intervention and three days after the start of the intervention. Method of measurement: Pulse oximetry of cardiac monitoring device and recording information in a questionnaire. Patient body temperature. Timepoint: Before the intervention and three days after the start of the intervention. Method of measurement: Digital thermometer (forehead temperature measurement). Severity of lung involvement. Timepoint: Before the intervention and three days after the start of the intervention. Method of measurement: Radiographic device. Severe shortness of breath. Timepoint: Before the intervention and three days after the start of the intervention. Method of measurement: Patient self-declaration. Islamic Azad University Approved 2021-04-10 Ethics committee of Tehran Islamic Azad University of Medical Sciences No: 403, Corner of Gol Yakh St., Aineh Blvd., Amir Paberja St., Gholhak Intersection, Dr.Shariati St. Tehran Tehran Iran (Islamic Republic of)