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IRCT20210613051559N1 IRCT 2021-06-19 Tehran University of Medical Sciences Comparison of the effect of intraarticular and periarticular injection of cocktail of morphin epinephrin ropivacain ketorolac on eliminating the postoperative pain after total knee arthroplasty in patients with knee degenerative joint disease Comparison of the effect of intraarticular and periarticular injection of cocktail of morphin epinephrin ropivacain ketorolac on eliminating the postoperative pain after total knee arthroplasty in patients with knee degenerative joint disease 2021-06-15 anticipated 96 Complete https://irct.ir/trial/56857 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: simple randomization triple blind (the patient the analyser and the researcher gathering datea are not informed of the type of allocation) the allocation of each patient is determined according to the numbers generated by randomization software and is documented in sealed envelope. during the operation, the envelope is opened and the surgeon is informed of the type of allocation at the time of prosthesis insertion by his operative staff, Blinding description: the allocation of each patient is determined according to the numbers generated by randomization software and is documented in sealed envelope. during the operation, the envelope is opened and the surgeon is informed of the type of allocation at the time of prosthesis insertion by his operative staff. 3 knee degenerative joint disease. Intervention 1: Intervention group: intrarticular analgesic cocktail (MS, ropivacain, ketorolac, epinephrin) injection 100 cc. Intervention 2: Intervention group: periarticular injection of analgesic cocktail 100 cc. Intervention 3: Intervention group: intra (50cc) and peri articular (50 cc) injection of analgesic cocktail. Yes - There is a plan to make this available What will be shared: Comparision of the effect of intraarticular and periarticular injection of coctail of morphin epinephrin ropivacain ketorolac on eliminating the postoperative pain after total knee arthroplasty in knee arthrotic patients referred to the joint reconstruction research center of imamkhomeini hospital When: at the end of the study To whom: academic institution Conditions: scientific journal Where to obtain: for comparing the clinical outcom the data is aimed to be shared online How to obtain: email request Comments:
public seyed mohammad javad mortazavi
Joint Reconstruction Research Center, Orthopedicsurgery department, Imam Khomeini Hospital, End of Keshavarz Blvd, Tehran1419733141, Iran.
Tehran Iran (Islamic Republic of) 1419733141 +98 21 8827 0873 smjmort@yahoo.com Tehran University of Medical Sciences scientific farzad vosoughi
Joint Reconstruction Research Center, Orthopedicsurgery department, Imam Khomeini Hospital, End of Keshavarz Blvd, Tehran1419733141, Iran.
tehran Iran (Islamic Republic of) 1419733141 009888270873 farzadvosooghi@gmail.com Tehran University of Medical Sciences Iran (Islamic Republic of) those aged 18-80 weight between 50-120 kg ability to read, write and complete informed consent 18 years 80 years Both drug sensitivity drug dependence neurologic disease psychiatric illness cardiac disease liver disease cardiac arrythmia Diabetes neuromuscular problem inflammatory arthritis e.g. RA renal disease Rehabilitation Rehabilitation Rehabilitation Intervention group: intrarticular analgesic cocktail (MS, ropivacain, ketorolac, epinephrin) injection 100 cc Intervention group: periarticular injection of analgesic cocktail 100 cc Intervention group: intra (50cc) and peri articular (50 cc) injection of analgesic cocktail Amount of post operative morphin sulfate injection after the total knee arthroplasty. Timepoint: during 72 hr after the total knee arthroplasty. Method of measurement: mg morphin injected by the nursery and documented in the patien's documents. Visual analogue scale. Timepoint: during 72 h postoperatively 1 week and 1 months after surgery. Method of measurement: 1 to 10 based on the VAS scale. WOMAC. Timepoint: 1 DAY before OR, 1 week and 1 month after OR. Method of measurement: womac scale. KSS. Timepoint: 1 DAY before OR, 1 week and 1 month after OR. Method of measurement: KSS scale. Tehran University of Medical Sciences Approved 2021-01-27 ethical review board of imam khomeini hospital, tehran university of medical sciences Imam Khomeini Hospital, End of Keshavarz Blvd, Tehran1419733141, Iran. Tehran Tehran Iran (Islamic Republic of)